PEPI PUTRI KAMILA, - (2024) ANALISIS EFEKTIVITAS TERAPI REGIMEN STR DENGAN REGIMEN BPaL PADA PASIEN MULTIDRUG RESISTANT TUBERCULOSIS (MDR-TB) DI RSUP Dr. HASAN SADIKIN BANDUNG. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Regimen BPaL (Bedaquiline, Pretomanid, Linezolid) dan regimen STR (Short Term regimen) merupakan regimen yang digunakan untuk pengobatan Tuberkulosis Resistan Obat (TBC RO) atau Multidrug-Resistant Tuberculosis (MDR-TB). Regimen BPaL dan regimen STR selama penggunaannya dikaitkan dengan efektivitas terapi dalam konversi kultur dan potensi efek sampingnya. Penelitian ini menjelaskan efektivitas terapi dan efek samping dalam penggunaan regimen tersebut. Desain penelitian menggunakan studi retrospektif dengan data yang bersumber dari Sistem Informasi Tuberkulosis Kementerian Kesehatan RI dan rekam medis. Populasi penelitian ini adalah pasien TBC RO yang memulai pengobatan pada Januari 2022 – Februari 2024 di RSUP Dr. Hasan Sadikin Bandung dengan jumlah sampel sebanyak 24 pasien regimen BPaL dan 24 pasien regimen STR. Hasil penelitian menunjukkan bahwa regimen BPaL dan regimen STR berdasarkan efektivitas terapi dalam rata-rata konversi kultur adalah bulan ke 3. Keberhasilan pengobatan pada pasien yang menggunakan regimen BPaL yaitu sebesar 96% dengan rata-rata durasi pengobatan 6 bulan sedangkan regimen STR sebesar 27% dengan rata-rata durasi pengobatan 11 bulan. Efek samping paling banyak yaitu mual dan muntah. Data keberhasilan pengobatan menunjukkan regimen BPaL lebih efektif secara terapi dibandingkan dengan regimen STR dilihat dari konversi kultur, keberhasilan pengobatan dan efek samping obat. ---- The regimen BPaL (Bedaquiline, Pretomanid, Linezolid) and the regimen STR (Short Term regimen) are regimens used for the treatment of Drug-Resistant Tuberculosis (TBC RO) or Multidrug Resistant Tuberculosis (MDR-TB). The BPaL regimen and STR regimen during use are associated with the effectiveness of therapy in culture conversion and the potential effects it causes. This study explains the effectiveness of therapy and side effects when using this regimen. The research design used a retrospective study with data sourced from the Indonesian Ministry of Health's Tuberculosis Information System and medical records. The population of this study were TB RO patients who started treatment in January 2022 – February 2024 at RSUP Dr. Hasan Sadikin Bandung with a total sample of 24 patients on the BPaL regimen and 24 patients on the STR regimen. The results of the study showed that the BPaL regimen and STR regimen based on therapeutic effectiveness in the average culture conversion was 3 months. Treatment success in patients using the BPaL regimen was 96% with an average treatment duration of 6 months while the STR regimen was 27% with the average duration of treatment was 11 months. The most side effects are nausea and vomiting. Treatment success data shows that the BPaL regimen is more therapeutically effective compared to the STR regimen in terms of culture conversion, treatment success and drug side effects.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | TBC RO, regimen BPaL, regimen STR, efektivitas terapi, keamanan. ----- TBC RO, regimen BPaL, regimen STR, therapeutic effectiveness, safety |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 19 Aug 2024 07:46 |
| Last Modified: | 19 Aug 2024 07:46 |
| URI: | http://repository.stfi.ac.id/id/eprint/962 |
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