REVIEW: POTENSI INHIBITOR TIROSINASE MEKANISME DIPHENOLASE DARI EKSTRAK ZINGIBERACEAE

DIANA ANGGRAENI, - (2021) REVIEW: POTENSI INHIBITOR TIROSINASE MEKANISME DIPHENOLASE DARI EKSTRAK ZINGIBERACEAE. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Inhibitor tirosinase merupakan senyawa yang dapat menghambat proses pembentukan melanin di lapisan epidermis sehingga dapat digunakan pada produk kosmetik sebagai pemutih. Inhibitor tirosinase yang telah popular di masyarakat adalah hidrokuinon dan asam kojat. Namun, hidrokuinon dan asam kojat diketahui dapat bersifat karsinogenik. Zingiberaceae merupakan salah satu keluarga tumbuhan asli Indonesia dan pemanfaatannya sudah banyak digunakan sebagai obat tradisional. Review ini bertujuan untuk mengumpulkan informasi tentang potensi ekstrak keluarga Zingiberaceae sebagai inhibitor tirosinase mekanisme diphenolase menggunakan pencarian secara online dari beberapa publikasi ilmiah baik nasional maupun internasional. Hasil yang digunakan dari beberapa studi literatur menunjukkan bahwa tanaman dari keluarga Zingiberaceae memiliki aktivitas sebagai inhibitor tirosinase. Bagian rimpang dan genus Curcuma dari Zingiberaceae adalah yang paling banyak dilaporkan sebagai inhibitor tirosinase. Dari genus ini, yang paling berpotensi memiliki aktivitas penghambatan tirosinase adalah ekstrak etanol 70% rimpang Curcuma mangga dengan nilai IC30 0,07 mg/ml. ICsə asam kojat dalam review ini sebagai kontrol positif pada rentang 0,01-0,04 mg/ml. Metode ekstraksi yang paling banyak dilakukan dalam pengujian potensi inhibitor tirosinase dari Zingiberaceae yaitu metode maserasi. Golongan fenol termasuk flavonoid dan antosianin diduga merupakan golongan senyawa yang berperan sebagai inhibitor tirosinase dari keluarga Zingiberaceae. ---- Tyrosinase inhibitors are compounds that can inhibit the process of melanin formation in the epidermis layer so that they can be used in cosmetic products as whitening agents. Tyrosinase inhibitors that have been popular in the community are hydroquinone and kojic acid. However, hydroquinone and kojic acid are known to be carcinogenic. Zingiberaceae is a family of plants native to Indonesia and its utilization has been widely used as traditional medicine. This review aims at gathering information on the potential of Zingiberaceae family extracts as inhibitors of the diphenolase tyrosinase mechanism using online searches of several scientific publications both nationally and internationally. The results used from several literature studies show that plants from the Zingiberaceae family have activity as tyrosinase inhibitors. The rhizome and genus Curcuma of Zingiberaceae are the most widely reported as tyrosinase inhibitors. Of this genus, the most likely to have tyrosinase inhibitory activity was the 70% ethanol extract of Curcuma mangga rhizome with ICsa 0.07 mg/ml. The ICso of kojic acid in this review as a positive control is in the range of 0.01-0.04 mg/ml. The most widely used extraction method in testing the potential for tyrosinase inhibitors from Zingiberaceae is the maceration method. The phenol group, including the forgotten flavonoids and anthocyanins, is a group of compounds that act as tyrosinase inhibitors from the Zingiberaceae family.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	inhibitor tirosinase, Zingiberaceae, rimpang. ----- tirosinase inhibitor, Zingiberaceae, rhizome.
Subjects:	R Medicine > R Medicine (General) R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Aug 2024 04:56
Last Modified:	14 Aug 2024 04:56
URI:	http://repository.stfi.ac.id/id/eprint/819

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