FORMULASI DAN KARAKTERISASI MICRONEEDLE α-MANGOSTIN VARIASI PERBANDINGAN PVA-PVP K30 DAN UJI PENETRASI IN VITRO

RIANINGSIH DWI ASTUTI M, - (2026) FORMULASI DAN KARAKTERISASI MICRONEEDLE α-MANGOSTIN VARIASI PERBANDINGAN PVA-PVP K30 DAN UJI PENETRASI IN VITRO. Masters thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Formulasi dissolving microneedle memerlukan polimer biokompatibel dengan kekuatan mekanik memadai untuk penetrasi kulit. Penelitian ini bertujuan mengoptimalkan kombinasi PVA-PVP K30 dan konsentrasi α-mangostin untuk menghasilkan Microneedle dengan karakteristik dan difusi in vitro yang baik. Penelitian meliputi validasi metode analisis, pembuatan melalui micromoulding, optimasi basis dan konsentrasi α-mangostin, serta pengujian difusi menggunakan Franz cell. Delapan formula basis dibuat dengan variasi rasio PVA:PVP K30. F1 tidak homogen, sedangkan F2-F8 homogen dengan bobot jenis 1,002-1,029 g/mL, viskositas 2,833-75,667 cP, dan pH 4,647-5,553. Basis yang dihasilkan memiliki LOD 1,897-15,913%, sharpness 8,389-12,150 N, fracture force 20,65-66,00 N, dan tensile strength 12,56-19,97 MPa. F6 dipilih sebagai basis pembawa α-mangostin 0,1-0,4%. Peningkatan konsentrasi α-mangostin menurunkan LOD dan kekuatan mekanik serta meningkatkan gaya penetrasi. Konsentrasi 0,2% menghasilkan karakteristik terbaik berupa tekstur keras, jarum tajam, seragam, dan elastis, dengan LOD 6,840%, sharpness 11,065 N, fracture force 28,35 N, dan tensile strength 14,13 MPa. Pengamatan SEM menunjukkan struktur jarum utuh, kompak, relatif seragam, dan memiliki ujung yang terdefinisi. Uji difusi menunjukkan peningkatan pelepasan α-mangostin hingga 48 jam dengan fluks 1,7072 µg/cm²/menit ± 0,0017 dan Q/A akhir 5.925,34 µg/cm² ± 10,21. ---- The formulation of dissolving Microneedles requires a biocompatible polymer with adequate mechanical strength for skin penetration. This study aimed to optimize the combination of PVA–PVP K30 and the concentration of α-mangostin to produce Microneedles with good characteristics and in vitro diffusion. The research included analytical method validation, fabrication via micromoulding, optimization of the base and α-mangostin concentration, and diffusion testing using a Franz cell. Eight base formulas were prepared with variations in the PVA:PVP K30 ratio. F1 was found to be non-homogeneous, whereas F2–F8 were homogeneous, with specific gravity of 1.002-1.029 g/mL, viscosity of 2.833-75.667 cP, and pH of 4.647–5.553. The resulting bases exhibited LOD of 1.897-15.913%, sharpness of 8.389–12.150 N, fracture force of 20.65-66.00 N, and tensile strength of 12.56- 19.97 MPa. F6 was selected as the carrier base for α-mangostin at concentrations of 0.1–0.4%. An increase in α-mangostin concentration decreased the LOD and mechanical strength while increasing the penetration force. The 0.2% concentration produced the best characteristics, namely a hard texture and needles that were sharp, uniform, and elastic, with an LOD of 6.840%, sharpness of 11.065 N, fracture force of 28.35 N, and tensile strength of 14.13 MPa. SEM observation revealed an intact, compact, relatively uniform needle structure with well-defined tips. The diffusion test showed an increase in α-mangostin release up to 48 hours, with a flux of 1,7072 µg/cm²/min ± 0,0017 and a final Q/A of 5.925,34 µg/cm² ± 10.21.

Item Type:	Thesis (Masters)
Uncontrolled Keywords:	Dissolving Microneedle, Polimer, Kombinasi PVA-PVP K30, αmangostin. ----Dissolving Microneedle, Polymer, PVA-PVP K30 combination, αmangostin.
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi Magister Farmasi > Tesis
Depositing User:	pustakawan - -
Date Deposited:	02 Nov 2026 03:28
Last Modified:	02 Nov 2026 03:28
URI:	http://repository.stfi.ac.id/id/eprint/4903

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