DISSOLVING MICRONEEDLES UNTUK PENGHANTARAN OBAT TRANSDERMAL: KAJIAN PUSTAKA SIFAT FISIKOKIMIA DAN DESAIN GEOMETRI

MUTMAINNAH SOLEMAN, - (2026) DISSOLVING MICRONEEDLES UNTUK PENGHANTARAN OBAT TRANSDERMAL: KAJIAN PUSTAKA SIFAT FISIKOKIMIA DAN DESAIN GEOMETRI. Health Research Journal of Indonesia, 4 (5). pp. 1978-1986. ISSN 2964-7592

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Abstract

Penghantaran obat secara transdermalmemiliki beberapa keunggulan dibandingkan rute oral, seperti menghindari metabolisme lintas pertama, mencegah degradasi di lambung, dan meminimalkan efek samping gastrointestinal. Namun, stratum korneum sebagai lapisan terluar kulit menjadi hambatan utamabagi permeasi obat secara pasif, sehingga hanya obat dengan sifat fisikokimia tertentu yang sesuai untuk rute ini. Dissolving Microneedle (DMN) adalah sistem penghantaran obat berbasis polimer yang dapat menembus stratum korneumsecara fisik, memungkinkan penghantaran berbagai zat aktif, termasuk makromolekul dan molekul hidrofilik, secara efisien dan tanpa rasa sakit. Kajian pustaka ini membahas pengaruh sifat fisikokimia zat aktif dan desain geometri jarum DMN terhadap efisiensi penghantaran obat transdermal. Hasil kajian menunjukkan bahwa parameter fisikokimiaseperti berat molekul, log P, dan kelarutan sangat menentukan kesesuaian zat aktif untuk sistem DMN. Selain itu, geometri jarum, meliputi bentuk, tinggi, diameter, dan sudut ujung, berpengaruh terhadap kekuatan mekanik, kemampuan penetrasi kulit, dan profil disolusi DMN. Jarum berbentuk konikal menunjukkan performa terbaik dalam rasio penyisipan kulit dan laju disolusi dibandingkan dengan bentuk lain. Pemahaman yang komprehensif mengenai hubungan antara sifat fisikokimiazat aktif dan desain geometri DMN sangat penting untuk mengoptimalkan formulasi dan meningkatkan efikasi terapi transdermal. ------- Transdermal drug delivery presents several advantages over oral administration, including bypassing first-pass metabolism, avoiding gastric degradation, and reducing gastrointestinal side effects. However, the outermost layer of the skin, known as the stratum corneum, acts as a primary barrier that limits passive drug permeation, thereby restricting this delivery route to drugs with specific physicochemical properties. Dissolving Microneedles (DMN) are polymer-based drug delivery systems that physically penetratethe stratum corneum, facilitating the efficient delivery of various active substances—including macromolecules and hydrophilic molecules—without causing pain. This literature review aims to investigate the impact of physicochemical properties of active substances and the geometric design of DMN needles on the efficiency of transdermal drug delivery. The review findings indicate that physicochemical parameters such as molecular weight, log P value, and solubility are significant determinants of a substance’s suitability for use within the DMN system. Additionally, needle geometry—including shape, height, diameter, and tip angle—has a demonstrable effect on the mechanical strength of DMN, its skin penetration capability, and its dissolution profile. The conical needle shape has demonstrated superior performance regarding skin insertion ratio and dissolution rate compared to alternative shapes. A comprehensive understanding of the relationship between physicochemical properties of active substances and the geometric design parameters of DMN is essential for optimizing formulations to enhance transdermal therapeutic efficacy.

Item Type:	Article
Uncontrolled Keywords:	dissolving microneedle, penghantaran obat transdermal, sifat fisikokimia, desain geometri jarum, stratum korneum. ------ dissolving microneedle, transdermal drug delivery, physicochemical properties, needle geometry design, stratum corneum
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Program Studi Magister Farmasi > Publikasi Artikel Ilmiah
Depositing User:	pustakawan - -
Date Deposited:	02 Nov 2026 02:17
Last Modified:	02 Nov 2026 02:18
URI:	http://repository.stfi.ac.id/id/eprint/4895

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