AMALIA FITRI, - (2026) OPTIMASI JENIS POLIMER BERDASARKAN RASIO KONSENTRASI TERHADAP PENINGKATAN KELARUTAN KURKUMIN DALAM AIR DENGAN SISTEM DISPERSI PADAT. Other thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Kurkumin merupakan senyawa aktif utama dari Curcuma longa L. yang memiliki berbagai aktivitas farmakologis, namun pemanfaatannya terbatas karena kelarutannya yang rendah dalam air. Penelitian ini bertujuan menentukan jenis polimer dan rasio kurkumin:polimer yang paling optimal dalam meningkatkan kelarutan kurkumin melalui sistem dispersi padat menggunakan metode solvent evaporation. Kurkumin diformulasikan dengan lima polimer hidrofilik, yaitu natrium alginat, PVP K30, PVP K90, PEG 6000, dan maltodekstrin pada rasio kurkumin:polimer 1:1, 1:2, dan 1:3 sehingga diperoleh 15 formula. Karakterisasi meliputi pengamatan preparasi, rendemen, uji higroskopis, Loss on Drying (LOD), serta uji kelarutan. Hasil penelitian menunjukkan bahwa seluruh formula berhasil membentuk sistem dispersi padat dengan karakteristik yang berbeda sesuai jenis dan rasio polimer. Penggunaan polimer hidrofilik meningkatkan kelarutan kurkumin dibandingkan kurkumin murni, dengan efektivitas yang dipengaruhi oleh jenis dan rasio polimer. Formula F6 yang menggunakan PVP K30 pada rasio kurkumin:polimer 1:3 menghasilkan persentase kurkumin terlarut tertinggi sebesar 70,847%, dengan rendemen 79,496%, higroskopisitas 1,39%, dan nilai LOD 6,05%, sehingga ditetapkan sebagai formula terbaik. Berdasarkan hasil tersebut, PVP K30 merupakan jenis polimer yang paling efektif dan rasio kurkumin:polimer 1:3 merupakan rasio paling optimal dalam meningkatkan kelarutan kurkumin melalui sistem dispersi padat menggunakan metode solvent evaporation. ------- Curcumin is the major active compound of Curcuma longa L. and possesses various pharmacological activities; however, its application is limited by its poor aqueous solubility. This study aimed to determine the most optimal polymer type and curcumin-to-polymer ratio for improving the solubility of curcumin through a solid dispersion system using the solvent evaporation method. Curcumin was formulated with five hydrophilic polymers, namely sodium alginate, PVP K30, PVP K90, PEG 6000, and maltodextrin, at curcumin-to-polymer ratios of 1:1, 1:2, and 1:3, resulting in 15 formulations. Characterization included preparation observation, percentage yield, hygroscopicity, Loss on Drying (LOD), and solubility testing. The results showed that all formulations successfully formed solid dispersion systems with different characteristics depending on the polymer type and ratio. The use of hydrophilic polymers increased the solubility of curcumin compared with pure curcumin, and the effectiveness was influenced by the polymer type and ratio. Formula F6, containing PVP K30 at a curcumin-to-polymer ratio of 1:3, exhibited the highest percentage of dissolved curcumin (70.847%), with a percentage yield of 79.496%, hygroscopicity of 1.39%, and an LOD value of 6.05%, and was therefore identified as the best formulation. Based on these findings, PVP K30 was the most effective polymer, and the curcumin-to-polymer ratio of 1:3 was the most optimal ratio for improving curcumin solubility through a solid dispersion system using the solvent evaporation method.
| Item Type: | Thesis (Other) |
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| Uncontrolled Keywords: | kurkumin, dispersi padat, solvent evaporation, polimer, kelarutan. ------- curcumin, solid dispersion, solvent evaporation, polymer, solubility. |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 24 Sep 2026 03:04 |
| Last Modified: | 24 Sep 2026 03:04 |
| URI: | http://repository.stfi.ac.id/id/eprint/4312 |
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