FORMULASI DAN UJI STABILITAS GRANUL INSTAN EKSTRAK DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg)

NASYWAA RIFAT AMRI, - (2026) FORMULASI DAN UJI STABILITAS GRANUL INSTAN EKSTRAK DAUN SUKUN (Artocarpus altilis (Parkinson) Fosberg). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Daun sukun (Artocarpus altilis (Parkinson) Fosberg) mengandung senyawa flavonoid yang berpotensi sebagai antihiperkolesterolemia, namun pemanfaatannya masih terbatas karena sediaan yang tersedia umumnya memiliki rasa yang kurang enak, kurang praktis dalam penggunaannya, serta stabilitas yang rendah. Untuk mengatasi permasalahan tersebut, daun sukun dalam bentuk ekstrak dapat diformulasikan dalam bentuk granul instan. Granul instan merupakan salah satu bentuk sediaan yang mudah digunakan, dapat menutupi rasa yang kurang enak, memiliki waktu pelarutan yang cepat, serta dapat meningkatkan stabilitas sediaan. Penelitian ini bertujuan untuk memperoleh formula optimum granul instan ekstrak daun sukun menggunakan metode Simplex Lattice Design (SLD) serta mengevaluasi stabilitas formula optimum. Formula dibuat dengan variasi konsentrasi maltodekstrin dan manitol sebagai bahan pengisi melalui metode granulasi basah. Evaluasi karakteristik fisik meliputi organoleptik, distribusi ukuran partikel, laju alir, sudut istirahat, indeks kompresibilitas, moisture content, pH, dan waktu melarut. Hasil evaluasi dianalisis menggunakan Simplex Lattice Design dan diperoleh formula optimum dengan komposisi maltodekstrin 32,074% dan manitol 46,926%. Formula optimum selanjutnya diuji stabilitas melalui pengamatan organoleptik, moisture content, dan cemaran mikroba. Hasil pengujian menunjukkan bahwa formula optimum memenuhi persyaratan karakteristik fisik granul instan dan tetap memenuhi persyaratan mutu selama penyimpanan tanpa perubahan yang bermakna. Dengan demikian, formula optimum granul instan ekstrak daun sukun memiliki karakteristik fisik yang baik dan stabil selama penyimpanan. ------- Breadfruit leaves (Artocarpus altilis (Parkinson) Fosberg) contain flavonoids with potential antihypercholesterolemic activity. However, their utilization remains limited because the available dosage forms generally have an unpleasant taste, limited convenience, and low stability. To overcome this limitation, breadfruit leaves in the form of an extract can be formulated as instant granules. Instant granules are a convenient dosage form that can mask the unpleasant taste, provide rapid dissolution, and enhance formulation stability. This study aimed to obtain the optimum formulation of breadfruit leaf extract instant granules using the Simplex Lattice Design (SLD) method and to evaluate its stability. The formulations were prepared by wet granulation using different proportions of maltodextrin and mannitol as filler excipients. Physical characteristics were evaluated based on organoleptic properties, particle size distribution, flow rate, angle of repose, compressibility index, moisture content, pH, and dissolution time. The evaluation results identified an optimum formulation containing 32.074% maltodextrin and 46.926% mannitol. The optimum formulation was subsequently subjected to stability testing by evaluating organoleptic properties, moisture content, and microbial contamination. The results showed that the optimum formulation met the required physical quality parameters and remained compliant with quality requirements throughout storage without significant changes. Therefore, the optimum breadfruit leaf extract instant granules exhibited good physical characteristics and stability under storage conditions.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	ekstrak daun sukun, granul instan, Simplex Lattice Design, stabilitas. ----- breadfruit leaf extract, instant granules, Simplex Lattice Design, stability
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	24 Sep 2026 02:17
Last Modified:	24 Sep 2026 02:17
URI:	http://repository.stfi.ac.id/id/eprint/4303

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