RISNA DEWI SAFITRI, - (2026) UJI IN SILICO: EFEKTIVITAS ISOLAT ANDROGRAFOLID (Andrographis paniculata) TERHADAP RESEPTOR (HMG-CoA REDUCTASE, PCSK9, PPAR-α, DAN NPC1L1) SEBAGAI ANTIHIPERLIPIDEMIA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Hiperlipidemia merupakan faktor risiko utama penyakit kardiovaskular yang ditandai dengan peningkatan kadar lipid dalam darah. Andrografolid, senyawa aktif utama dari Andrographis paniculata diketahui memiliki potensi sebagai antihiperlipidemia. Penelitian ini bertujuan mengevaluasi potensi andrografolid terhadap reseptor HMG-CoA Reduktase, PCSK9, PPAR-α, dan NPC1L1 menggunakan pendekatan in silico serta menilai kelayakannya sebagai kandidat obat melalui prediksi Lipinski’s Rule of Five, toksisitas, dan potensi aktivitas. Hasil penelitian menunjukkan bahwa andrografolid memenuhi seluruh parameter Lipinski's Rule of Five dan diprediksi memiliki toksisitas relatif rendah dengan nilai LD₅₀ sebesar 1890 mg/kgBB, meskipun diprediksi berpotensi imunotoksisitas. Prediksi potensi aktivitas menunjukkan bahwa andrografolid berpotensi sebagai agen antihiperlipidemia. Hasil penambatan molekuler menunjukkan andrografolid memiliki energi ikatan terhadap HMG-CoA Reduktase, PCSK9, PPAR-α, dan NPC1L1 berturut-turut sebesar -8,01; -8,44; -8,41; dan -5,90 kcal/mol. Berdasarkan hasil analisis, HMG-CoA Reduktase menjadi target molekuler yang paling potensial bagi andrografolid karena memiliki pola interaksi yang paling mendukung kestabilan kompleks ligan-reseptor. ------- Hyperlipidemia is a major risk factor for cardiovascular disease characterized by elevated lipid levels in the blood. Andrographolide, the major active compound of Andrographis paniculata, is known to have potential antihyperlipidemic activity. This study aimed to evaluate the potential of andrographolide against HMG-CoA Reductase, PCSK9, PPAR-α, and NPC1L1 receptors using an in silico approach and to assess its potential as a drug candidate through predictions of Lipinski’s Rule of Five, toxicity, and biological activity. The results showed that andrographolide met all parameters of Lipinski’s Rule of Five and was predicted to have relatively low toxicity with an LD₅₀ value of 1890 mg/kgBW, although it was predicted to have immunotoxic potential. Biological activity prediction indicated that andrographolide has potential as an antihyperlipidemic agent. Molecular docking results showed that andrographolide had binding energies of −8.01, −8.44, −8.41, and −5.90 kcal/mol against HMG-CoA Reductase, PCSK9, PPARα, and NPC1L1, respectively. Based on the analysis, HMG-CoA Reductase was identified as the most potential molecular target for andrographolide due to its interaction pattern, which was considered to support the stability of the ligand– receptor complex.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Andrografolid, antihiperlipidemia, in silico, molecular docking, HMG-CoA Reduktase. ----- Andrographolide, antihyperlipidemic, in silico, molecular docking, HMG-CoA Reductase. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 24 Sep 2026 01:59 |
| Last Modified: | 24 Sep 2026 01:59 |
| URI: | http://repository.stfi.ac.id/id/eprint/4299 |
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