PEMBENTUKAN POLIMER UNTUK MOLECULARLY IMPRINTED POLYMER (MIP) DARI ALFA-MANGOSTIN DAN METAKRILAT ANHIDRIDA

YOLGA TRIANA PUTRI, - (2026) PEMBENTUKAN POLIMER UNTUK MOLECULARLY IMPRINTED POLYMER (MIP) DARI ALFA-MANGOSTIN DAN METAKRILAT ANHIDRIDA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Alfa-mangostin merupakan senyawa xanton dari kulit buah manggis (Garcinia mangostana L.) yang sulit diperoleh dalam kemurnian tinggi melalui metode pemisahan konvensional. Molecularly Imprinted Polymer (MIP) berbasis interaksi kovalen berpotensi meningkatkan selektivitas pemurnian. Penelitian ini bertujuan membentuk monomer metakriloil mangostin melalui esterifikasi alfa-mangostin dengan metakrilat anhidrida. Metode meliputi sintesis menggunakan katalis DMAP, pemurnian dengan ekstraksi cair-cair dan kromatografi kolom gravitasi, karakterisasi dengan UV-Vis, FTIR, dan penentuan bilangan ester, serta polimerisasi presipitasi menggunakan EGDMA dan AIBN. Hasil KLT menunjukkan reaksi esterifikasi stabil pada jam ke-8. Karakterisasi FTIR menunjukkan munculnya pita karbonil ester pada 1744,35 cm⁻¹, dengan bilangan ester 235,498 mg KOH/g dan Derajat substitusi 2,42. Polimerisasi menghasilkan polimer dengan rendemmen rendah (0,026 gram dari 0,4 gram monomer) akibat kelarutan monomer yang kurang sempurna dan purging nitrogen yang belum optimal. Spektrum FTIR polimer masih menunjukkan pita O-H, C=O, dan C=C, mengindikasikan templat masih berada dalam matriks polimer. Metakriloil mangostin berhasil disintesis, namun MIP fungsional belum sepenuhnya terbentuk. ------ Alpha-mangostin is a xanthone compound found in the pericarp of mangosteen (Garcinia mangostana L.) that is difficult to obtain at high purity through conventional separation methods. A covalent-interaction-based Molecularly Imprinted Polymer (MIP) has the potential to improve purification selectivity. This study aimed to synthesize a methacryloyl mangostin monomer through the esterification of alpha-mangostin with methacrylic anhydride. The method included synthesis using a DMAP catalyst, purification by liquid–liquid extraction and gravity column chromatography, characterization by UV-Vis spectrophotometry, FTIR, and ester value determination, followed by precipitation polymerization using EGDMA and AIBN. TLC monitoring showed that the esterification reaction at the 8 hours. FTIR characterization revealed the emergence of an ester carbonyl band at 1744.35 cm⁻¹, with an ester value of 235.498 mg KOH/g and a degree of substitution of 2.42. Polymerization yielded a low amount of polymer (0.026 g from 0.4 g of monomer), attributed to incomplete monomer solubility and suboptimal nitrogen purging. The polymer's FTIR spectrum still exhibited O–H, C=O, and C=C bands, indicating that the template remained present within the polymer matrix. Methacryloyl mangostin was successfully synthesized; however, a fully functional MIP was not yet obtained, so further optimization is required.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Alfa-mangostin, metakriloil mangostin, esterifikasi, Molecularly Imprinted Polymer, Polimerisasi presipitasi ----- Alpha-mangostin, methacryloyl mangostin, esterification, Molecularly Imprinted Polymer, precipitation polymerization
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	23 Sep 2026 07:42
Last Modified:	23 Sep 2026 07:42
URI:	http://repository.stfi.ac.id/id/eprint/4290

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