OPTIMASI FORMULA DAN EVALUASI SEDIAAN KRIM ISOLAT KATEKIN DENGAN METODE SIMPLEX LATTICE DESIGN (SLD)

GHAIDA RAHMA OKTORIA, - (2026) OPTIMASI FORMULA DAN EVALUASI SEDIAAN KRIM ISOLAT KATEKIN DENGAN METODE SIMPLEX LATTICE DESIGN (SLD). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Katekin merupakan senyawa polifenol yang memiliki aktivitas antioksidan dan berpotensi dikembangkan dalam bentuk sediaan topikal berupa krim. Penggunaan emulgator dalam formulasi krim berperan penting dalam menghasilkan sediaan dengan karakteristik fisik yang memenuhi persyaratan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi asam stearat dan trietanolamin (TEA) terhadap karakteristik fisik sediaan krim isolat katekin serta menentukan formula optimum menggunakan metode Simplex Lattice Design (SLD). Penelitian dilakukan dengan memvariasikan konsentrasi asam stearat dan trietanolamin pada beberapa formula krim. Evaluasi sediaan meliputi uji organoleptis, homogenitas, tipe emulsi, pH, viskositas, daya sebar, dan daya lekat. Optimasi formula dilakukan berdasarkan respon pH dan viskositas menggunakan metode SLD. Hasil penelitian menunjukkan bahwa variasi konsentrasi asam stearat dan trietanolamin memberikan pengaruh terhadap karakteristik fisik sediaan, terutama pada respon pH dan viskositas. Formula optimum yang dipilih adalah Formula 4 dengan kombinasi asam stearat sebesar 17% dan trietanolamin sebesar 3%, karena menghasilkan karakteristik fisik yang sesuai dengan parameter sediaan krim topikal. Formula optimum tersebut menghasilkan nilai prediksi viskositas sebesar 44.152,6 cPs dan pH sebesar 7,5 dengan nilai desirability sebesar 1,000. Berdasarkan hasil penelitian, metode Simplex Lattice Design dapat digunakan untuk menentukan formula optimum krim isolat katekin dengan karakteristik fisik yang memenuhi persyaratan sediaan topikal. ------- Catechin is a polyphenolic compound that exhibits antioxidant activity and has the potential to be developed into a topical cream preparation. The use of emulsifiers in cream formulations plays an important role in producing preparations with physical characteristics that meet the required standards. This study aimed to determine the effect of varying concentrations of stearic acid and triethanolamine (TEA) on the physical characteristics of catechin isolate cream and to determine the optimum formula using the Simplex Lattice Design (SLD) method. The study was conducted by varying the concentrations of stearic acid and triethanolamine in several cream formulations. The evaluations included organoleptic properties, homogeneity, emulsion type, pH, viscosity, spreadability, and adhesion tests. Formula optimization was performed based on pH and viscosity responses using the SLD method. The results showed that variations in the concentrations of stearic acid and triethanolamine affected the physical characteristics of the cream preparation, particularly the pH and viscosity responses. The optimum formula selected was Formula 4, consisting of 17% stearic acid and 3% triethanolamine, as it produced physical characteristics that met the parameters for topical cream preparations. The optimum formula resulted in a predicted viscosity value of 44,152.6 cPs and a pH value of 7.5, with a desirability value of 1.000. Based on the results, the Simplex Lattice Design method can be applied to determine the optimum formula of catechin isolate cream with physical characteristics that meet the requirements of topical preparations

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Katekin, krim, asam stearat, trietanolamin, Simplex Lattice Design. ----- Catechin, cream, stearic acid, triethanolamine, Simplex Lattice Design.
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	23 Sep 2026 06:53
Last Modified:	23 Sep 2026 06:53
URI:	http://repository.stfi.ac.id/id/eprint/4280

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