PEMURNIAN EKSTRAK BRAZILIN BERBASIS MEKANISME PERTUKARAN ION MENGGUNAKAN ORGANOBENTONIT

YONA PIUINTAI, - (2026) PEMURNIAN EKSTRAK BRAZILIN BERBASIS MEKANISME PERTUKARAN ION MENGGUNAKAN ORGANOBENTONIT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Brazilin merupakan senyawa aktif utama dalam kayu secang (Caesalpinia sappan L.) yang masih bercampur dengan berbagai komponen lain dalam ekstrak sehingga diperlukan proses pemurnian. Maksud dari penelitian ini adalah memodifikasi bentonit untuk pemurnian senyawa polifenol, dengan brazilin sebagai senyawa model. Penelitian ini bertujuan menentukan nilai kapasitas tukar kation (KTK) organobentonit, menentukan pH dan waktu kontak optimum pada pemurnian ekstrak brazilin, serta menilai tingkat kemurnian hasil pemurnian menggunakan spektrofotometri UV-Vis. Pemurnian dilakukan menggunakan bentonit termodifikasi CTAB melalui mekanisme adsorpsi berbasis pertukaran ion. Hasil penelitian menunjukkan nilai KTK sebesar 40,6 meq/100 g dan karakterisasi FTIR mengonfirmasi keberhasilan modifikasi bentonit menjadi organobentonit. Kondisi optimum pemurnian diperoleh pada pH 7 dengan waktu kontak 10 menit. Analisis spektrofotometri UV-Vis menunjukkan bahwa hasil pemurnian memiliki profil spektrum yang lebih mendekati spektrum standar brazilin pada daerah serapan 450 nm, dengan peningkatan kemurnian brazilin sebesar 48,22%. Berdasarkan hasil tersebut, organobentonit berpotensi digunakan sebagai adsorben untuk meningkatkan kemurnian brazilin. ------ Brazilin is the major bioactive compound in sappan wood (Caesalpinia sappan L.) that is still mixed with various other components in the extract; therefore, a purification process is required. This study was intended to modify bentonite for the purification of polyphenolic compounds, with brazilin serving as the model compound. This study aimed to determine the cation exchange capacity (CEC) of organobentonite, identify the optimum pH and contact time for brazilin extract purification, and evaluate the purity of the purified brazilin using UV-Vis spectrophotometry. The purification process was carried out using CTAB-modified organobentonite through an adsorption mechanism based on ion exchange. The results showed that the organobentonite had a cation exchange capacity of 40.6 meq/100 g, and FTIR characterization confirmed the successful modification of bentonite into organobentonite. The optimum purification conditions were obtained at pH 7 with a 10-minute contact time. UV-Vis spectrophotometric analysis showed that the purified sample exhibited a spectral profile more closely resembling the brazilin standard in the absorption region of 450 nm, with an increase in brazilin purity of 48,22%. Based on these findings, organobentonite demonstrated potential as an adsorbent for improving brazilin purity.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	brazilin, organobentonit, pemurnian, pertukaran ion, spektrofotometri UV-Vis. ------ brazilin; ion exchange; organobentonite; purification; UV-Vis spectrophotometry
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	23 Sep 2026 04:47
Last Modified:	23 Sep 2026 04:47
URI:	http://repository.stfi.ac.id/id/eprint/4278

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