PEMBUATAN POLIMER UNTUK MOLECULARLY IMPRINTED POLYMER (MIP) BERBASIS KUERSETIN DAN METAKRILAT ANHIDRIDA

MUHAMMAD THORIQ FATHURROSYAD, - (2026) PEMBUATAN POLIMER UNTUK MOLECULARLY IMPRINTED POLYMER (MIP) BERBASIS KUERSETIN DAN METAKRILAT ANHIDRIDA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Kuersetin merupakan senyawa flavonoid yang dikenal memiliki aktivitas antioksidan, namun penggunaannya sebagai molekul template pada Molecularly Imprinted Polymer (MIP) kovalen masih terbatas karena tidak memiliki gugus vinil yang diperlukan dalam proses polimerisasi. Penelitian ini bertujuan mensintesis metakriloil kuersetin melalui reaksi esterifikasi menggunakan metakrilat anhidrida, mengkarakterisasi produk hasil sintesis, serta mensintesis polimer berbasis turunan tersebut sebagai tahap awal pengembangan Molecularly Imprinted Polymer (MIP) berbasis kuersetin. Esterifikasi dilakukan menggunakan katalis 4- Dimetilaminopiridina (DMAP) dalam pelarut Dimetilformamida (DMF). Produk hasil sintesis dikarakterisasi menggunakan Fourier Transform Infrared (FTIR), spektrofotometri UV-Vis, penentuan bilangan ester, dan derajat substitusi, kemudian dipolimerisasi menggunakan Etilen Glikol Dimetakrilat (EGDMA) sebagai crosslinker dan Azobisisobutironitril (AIBN) sebagai inisiator. Hasil penelitian menunjukkan bahwa turunan metakriloil kuersetin berhasil disintesis, yang ditandai dengan munculnya pita karbonil ester pada 1742,63 cm⁻¹, perubahan λmaks dari 256 dan 373 nm menjadi 255 dan 303 nm, nilai bilangan ester sebesar 324,58 mg KOH/g, dan derajat substitusi sebesar 2,91. Karakterisasi FTIR terhadap polimer menunjukkan hilangnya pita gugus vinil pada 944,89 cm⁻¹, yang menandakan gugus metakrilat telah berhasil mengalami polimerisasi. ----- Quercetin is a flavonoid well known for its antioxidant activity; however, its application as a template molecule in covalent Molecularly Imprinted Polymer (MIP) systems remains limited because it lacks the vinyl group required for polymerization. This study aimed to synthesize methacryloyl quercetin through an esterification reaction using methacrylic anhydride, characterize the synthesized product, and prepare a polymer based on the obtained derivative as an initial step in the development of quercetin-based Molecularly Imprinted Polymer (MIP). Esterification was carried out using 4-Dimethylaminopyridine (DMAP) as a catalyst in dimethylformamide (DMF). The synthesized product was characterized using Fourier Transform Infrared (FTIR) spectroscopy, UV-Visible spectrophotometry, ester value determination, and degree of substitution analysis, followed by polymerization using Ethylene Glycol Dimethacrylate (EGDMA) as the crosslinker and Azobisisobutyronitrile (AIBN) as the initiator. The results demonstrated the successful synthesis of methacryloyl quercetin, indicated by the appearance of an ester carbonyl absorption band at 1742.63 cm⁻¹, a shift in λmax from 256 and 373 nm to 255 and 303 nm, an ester value of 324.58 mg KOH/g, and a degree of substitution of 2.91. FTIR characterization of the polymer showed the disappearance of the vinyl absorption band at 944.89 cm⁻¹, indicating successful polymerization of the methacrylate group

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	kuersetin, metakrilat anhidrida, esterifikasi, molecularly imprinted polymer, metakriloil kuersetin. ------ quercetin, methacrylic anhydride, esterification, molecularly imprinted polymer, methacryloyl quercetin.
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	23 Sep 2026 04:40
Last Modified:	23 Sep 2026 04:40
URI:	http://repository.stfi.ac.id/id/eprint/4277

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