AISYAH SUKARMAN, - (2026) FORMULASI DAN EVALUASI TABLET LACTAGOGUE KOMBINASI EKSTRAK HERBA GINSENG JAWA (TALINUM PANICULATUM GAERTN) DAN EKSTRAK IKAN GABUS (CHANNA STRIATA). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Produksi air susu ibu (ASI) dipengaruhi oleh keseimbangan hormonal dan status nutrisi ibu. Herba ginseng jawa (Talinum paniculatum Gaertn.) berpotensi sebagai lactagogue karena mengandung flavonoid, dan saponin sedangkan ekstrak ikan gabus (Channa striata) mengandung albumin yang berperan dalam memperbaiki status nutrisi. Penelitian ini bertujuan memformulasikan kombinasi ekstrak herba ginseng jawa dan ekstrak ikan gabus menjadi sediaan tablet menggunakan metode granulasi kering serta mengevaluasi karakteristik granul dan mutu fisik tablet dengan variasi kombinasi mikrokristalin selulosa (MCC) dan laktosa. Penelitian dilakukan secara eksperimental melalui tahap determinasi tanaman, karakterisasi simplisia, penapisan fitokimia, ekstraksi, formulasi, pembuatan granul, evaluasi massa siap cetak, dan evaluasi tablet. Parameter granul meliputi distribusi ukuran partikel, kompresibilitas, laju alir, sudut diam, dan kadar kelembaban, sedangkan evaluasi tablet meliputi keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan, dan waktu hancur. Hasil penelitian menunjukkan bahwa kombinasi ekstrak herba ginseng jawa dan ekstrak ikan gabus berhasil diformulasikan menjadi tablet dengan metode granulasi kering. Variasi kombinasi MCC dan laktosa menghasilkan perbedaan karakteristik granul dan mutu fisik tablet pada masingmasing formula, dengan formula optimum memenuhi persyaratan mutu fisik sesuai Farmakope Indonesia Edisi VI. Dengan demikian, kombinasi kedua ekstrak berpotensi dikembangkan sebagai sediaan tablet lactagogue berbahan alam. -------- Breast milk production is influenced by hormonal balance and maternal nutritional Breast milk (breastfeeding) production is influenced by hormonal balance and maternal nutritional status. Javanese ginseng herb (Talinum paniculatum Gaertn.) has potential as a lactagogue due to its flavonoid, and saponin content, while snakehead fish extract (Channa striata) contains albumin, which contributes to improving nutritional status. This study aimed to formulate a combination of Javanese ginseng herb extract and snakehead fish extract into tablets using the dry granulation method and to evaluate the granule characteristics and physical quality of the tablets with varying combinations of microcrystalline cellulose (MCC) and lactose. The study was conducted experimentally through plant identification, crude drug characterization, phytochemical screening, extraction, formulation, granule preparation, evaluation of the ready-to-compress mass, and tablet evaluation. The granule parameters included particle size distribution, compressibility, flow rate, angle of repose, and moisture content, while tablet evaluation included weight uniformity, size uniformity, hardness, friability, and disintegration time. The results showed that the combination of Javanese ginseng herb extract and snakehead fish extract was successfully formulated into tablets using the dry granulation method. Variations in the combination of MCC and lactose resulted in differences in granule characteristics and physical quality among the formulations, with the optimum formulation meeting the physical quality requirements according to the Indonesian Pharmacopoeia, Sixth Edition. Therefore, the combination of the two extracts has potential for further development as a natural lactagogue tablet preparation.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Ginseng jawa, ikan gabus, lactagogue, granulasi kering, tablet, mikrokristalin selulosa, laktosa. ------- Javanese ginseng, snakehead fish, lactagogue, dry granulation, tablet |
| Subjects: | Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 23 Sep 2026 02:58 |
| Last Modified: | 23 Sep 2026 02:58 |
| URI: | http://repository.stfi.ac.id/id/eprint/4271 |
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