AURA NABILAH AR RAHMAH, - (2026) FORMULASI DAN EVALUASI SEDIAAN LOSION TABIR SURYA MENGANDUNG ALFA-MANGOSTIN (Garcinia mangostana Linn) SEBAGAI ANTIOKSIDAN SERTA PENENTUAN NILAI SPF SECARA IN VITRO. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Paparan radiasi ultraviolet (UV) dapat menyebabkan kerusakan kulit melalui pembentukan radikal bebas sehingga diperlukan sediaan tabir surya yang juga memiliki aktivitas antioksidan. Alfa-mangostin dari kulit buah manggis (Garcinia mangostana Linn.) diketahui memiliki aktivitas antioksidan kuat dan potensi fotoprotektif. Penelitian ini bertujuan memperoleh formula basis losion optimum menggunakan Simplex-Lattice Design (SLD), serta menentukan aktivitas antioksidan dan nilai Sun Protection Factor (SPF) secara in vitro. Optimasi dilakukan terhadap kombinasi asam stearat dan trietanolamin dengan respon pH, viskositas, daya sebar, dan daya lekat. Formula optimum kemudian diformulasikan dengan alfa-mangostin, dievaluasi karakteristik fisik, diuji stabilitas, aktivitas antioksidan menggunakan metode DPPH, serta ditentukan nilai SPF menggunakan metode spektrofotometri UV-Vis berdasarkan persamaan Mansur. Hasil optimasi formula optimum terdiri atas TEA 3,07% dan asam stearat 1,93%. Formula optimum memiliki pH 6,80, viskositas 20.833 cP, daya sebar 5,47 cm, dan daya lekat 40,71 detik serta memenuhi persyaratan mutu fisik. Isolat α-mangostin menunjukkan nilai IC50 sebesar 5,47 ppm dan nilai SPF sebesar 40,7 pada konsentrasi 500 ppm, sedangkan losion memiliki nilai IC50 sebesar 52,61 ppm dan nilai SPF sebesar 38,15 yang termasuk kategori proteksi ultra. Berdasarkan hasil penelitian, formula losion optimum memenuhi karakteristik fisik yang baik, stabil, serta memiliki aktivitas antioksidan dan kemampuan proteksi terhadap sinar UV yang baik. ------ Ultraviolet (UV) radiation exposure can cause skin damage through the formation of free radicals, highlighting the need for sunscreen formulations with antioxidant activity. α-Mangostin derived from mangosteen peel (Garcinia mangostana Linn.) is known to possess strong antioxidant and photoprotective properties. This study aimed to obtain the optimum lotion base formulation using the Simplex-Lattice Design (SLD) approach and to determine the antioxidant activity and in vitro Sun Protection Factor (SPF). Optimization was performed by varying the proportions of stearic acid and triethanolamine using pH, viscosity, spreadability, and adhesiveness as response variables. The optimum formulation was subsequently incorporated with α-mangostin, followed by evaluation of its physical characteristics, stability testing, antioxidant activity using the DPPH method, and SPF determination by UV-Visible spectrophotometry based on the Mansur equation. The optimum formulation consisted of 3.07% triethanolamine and 1.93% stearic acid. The optimized lotion exhibited a pH of 6.80, viscosity of 20,833 cP, spreadability of 5.47 cm, and adhesiveness of 40.71 s, meeting the required physical quality parameters. The α-mangostin isolate showed an IC₅₀ value of 5.47 ppm and an SPF value of 40.7 at a concentration of 500 ppm, whereas the α-mangostin lotion exhibited an IC₅₀ value of 52.61 ppm and an SPF value of 38.15, which is classified as ultra protection. In conclusion, the optimized lotion formulation demonstrated satisfactory physical characteristics, good stability, antioxidant activity, and effective in vitro UV protection.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Alfa-mangostin, Antioksidan, Losion, SPF, Simplex Lattice Design. ----- alpha-mangostin, antioxidant, lotion, SPF, Simplex-Lattice Design |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 23 Sep 2026 02:02 |
| Last Modified: | 23 Sep 2026 02:02 |
| URI: | http://repository.stfi.ac.id/id/eprint/4267 |
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