ERICA RAMADHANI, - (2026) FORMULASI DAN EVALUASI GRANUL INSTAN LACTAGOGUE EKSTRAK GINGSENG JAWA (Talinum Paniculatum Gaertn.) KOMBINASI EKSTRAK IKAN GABUS (Channa striata). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Air susu ibu (ASI) merupakan sumber nutrisi utama bagi bayi, namun tidak semua ibu mampu memproduksi ASI dalam jumlah yang mencukupi sehingga diperlukan alternatif laktagogum berbahan alam. Penelitian ini bertujuan memformulasikan dan mengevaluasi granul instan Lactagogue kombinasi ekstrak gingseng Jawa (Talinum paniculatum Gaertn.) dan Ekstrak ikan gabus (Channa striata), serta menentukan formula optimum menggunakan metode Simplex Lattice Design (SLD). Penelitian meliputi karakterisasi simplisia, skrining fitokimia, pembuatan granul instan dengan metode granulasi basah, serta evaluasi organoleptik, pH, distribusi ukuran partikel, laju alir, sudut istirahat, kompresibilitas, waktu larut, dan loss on drying (LOD). Formula optimum yang diperoleh memiliki nilai LOD 2,53%, kompresibilitas 11,12%, laju alir 48,69 g/detik, sudut istirahat 8,86°, waktu larut 45,74 detik, pH 4,33, dan distribusi ukuran partikel 6,91%, sehingga memenuhi persyaratan mutu granul instan. Dengan demikian, kombinasi ekstrak gingseng Jawa dan ekstrak ikan gabus berpotensi dikembangkan sebagai sediaan granul instan Lactagogue yang praktis dan bermutu. ----- Breast milk (ASI) is the main source of nutrition for babies, but not all mothers are able to produce sufficient breast milk, so alternative natural Lactagogues are needed. This study aims to formulate and evaluate instant Lactagogue granules combined with Javanese ginseng extract (Talinum paniculatum Gaertn.) and snakehead fish extract (Channa striata), and determine the optimum formula using the Simplex Lattice Design (SLD) method. The study includes characterization of simplicia, phytochemical screening, production of instant granules using the wet granulation method, and organoleptic evaluation, pH, particle size distribution, flow rate, angle of repose, compressibility, dissolution time, and loss on drying (LOD). The optimum formula obtained has a LOD value of 2.53%, compressibility of 11.12%, flow rate of 48.69 g/sec, angle of repose of 8.86°, dissolution time of 45.74 seconds, pH of 4.33, and particle size distribution of 6.91%, thus meeting the quality requirements of instant granules. Thus, the combination of Javanese ginseng extract and snakehead fish albumin has the potential to be developed as a practical and high-quality instant Lactagogue granule preparation.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | granul instan, laktagogum, Talinum paniculatum, ekstrak ikan gabus, Simplex Lattice Design (SLD). ----- instant granules, lactagogum, Talinum paniculatum, snakehead fish extract, Simplex Lattice Design (SLD). |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 22 Sep 2026 03:14 |
| Last Modified: | 22 Sep 2026 03:14 |
| URI: | http://repository.stfi.ac.id/id/eprint/4261 |
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