WAYAN KRISNA, - (2025) POTENSI AKTIVITAS MUKOLITIK DEKOKTA KOMBINASI JAHE MERAH (Zingiber officinale var. rubrum) DAN BATANG SERAI WANGI (Cymbopogon nardus L.) SECARA IN VITRO. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Jahe merah (Zingiber officinale var. rubrum) dan batang serai wangi (Cymbopogon nardus L.) diketahui mengandung senyawa aktif yang berpotensi sebagai mukolitik alami. Penelitian ini bertujuan untuk mengetahui potensi aktivitas mukolitik dekokta kombinasi jahe merah dan batang serai wangi secara in vitro terhadap penurunan viskositas putih telur bebek. Penelitian dilakukan dengan 12 kelompok perlakuan, meliputi kontrol normal, negatif, positif, dekokta jahe merah dan batang serai wangi tunggal (5%, 10%, 20%), serta kombinasi keduanya dengan rasio 1:1, 3:1, dan 1:3. Pengukuran viskositas dilakukan menggunakan viskometer Brookfiled pada interval waktu 0–60 menit. Data dianalisis dengan uji One Way ANOVA untuk mentahui perbedaan antar kelompok. Hasil penelitian menunjukkan bahwa semua kelompok perlakuan mengalami penurunan viskositas, dengan kombinasi jahe merah dan batang serai wangi rasio 3:1 memberikan penurunan terbesar sebesar 78,40%, mendekati kontrol positif sebesar 80,25%. Analisis statistik menunjukkan perbedaan signifikan antar kelompok (p < 0,05). Dapat disimpulkan bahwa dekokta kombinasi jahe merah dan serai wangi memiliki aktivitas mukolitik signifikan secara in vitro, dan kombinasi rasio 3:1 merupakan formulasi paling efektif dalam menurunkan viskositas. ------- Red ginger (Zingiber officinale var. rubrum) and lemongrass stalks (Cymbopogon nardus L.) are known to contain active compounds with potential as natural mucolytic agents. This study aimed to evaluate the mucolytic activity of a decoction combining red ginger and lemongrass stalks in vitro based on their ability to reduce the viscosity of duck egg white as a mucus model. The research consisted of 12 treatment groups, including normal, negative, and positive controls, single decoctions of red ginger and lemongrass at concentrations of 5%, 10%, and 20%, as well as combinations of both in ratios of 1:1, 3:1, and 1:3. Viscosity measurements were performed using a Brookfield viscometer at 0–60 minute intervals. Data were analyzed using a One Way ANOVA test to determine significant differences among groups. The results showed that all treatment groups caused a decrease in viscosity, with the combination of red ginger and lemongrass at a 3:1 ratio producing the greatest reduction (78.40%), approaching that of the positive control (80.25%). Statistical analysis indicated a significant difference among the groups (p < 0.05). It can be concluded that the decoction combination of red ginger and lemongrass possesses significant mucolytic activity in vitro, with the 3:1 ratio being the most effective formulation in reducing viscosity.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | jahe merah, batang serai wangi, dekokta, mukolitik, viskositas, in vitro. ------- red ginger, lemongrass stalk, decoction, mucolytic, viscosity, in vitro |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 21 Nov 2025 03:49 |
| Last Modified: | 21 Nov 2025 03:49 |
| URI: | http://repository.stfi.ac.id/id/eprint/3549 |
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