PENGARUH KADAR PENGIKAT DAN PENGHANCUR TERHADAP MUTU DAN DISOLUSI BRAZILIN DARI SEDIAAN PADAT ORAL YANG DI BUAT SECARA GRANULASI

MELISA ALFRIANI, - (2025) PENGARUH KADAR PENGIKAT DAN PENGHANCUR TERHADAP MUTU DAN DISOLUSI BRAZILIN DARI SEDIAAN PADAT ORAL YANG DI BUAT SECARA GRANULASI. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh variasi kadar bahan pengikat PVP K-30 dan bahan penghancur Primogel (Sodium Starch Glycolate) terhadap mutu fisik granul serta karakteristik tablet isolat brazilin. Metode yang digunakan adalah granulasi basah dengan empat formula yang mengandung isolat brazilin 40% dan variasi konsentrasi PVP K-30 (2% dan 4%) serta Primogel (2% dan 4%). Evaluasi granul meliputi uji kelembapan, laju alir, kompresibilitas, sudut istirahat, dan distribusi ukuran partikel. Evaluasi tablet meliputi keseragaman bobot, kekerasan, waktu hancur, friabilitas, dan profil disolusi. Hasil penelitian menunjukkan bahwa variasi kadar PVP K-30 dan Primogel memberikan pengaruh signifikan terhadap sifat fisik granul maupun tablet. Peningkatan konsentrasi PVP K-30 meningkatkan kekompakan dan kekerasan tablet, namun memperlambat waktu hancur dan disolusi. Sebaliknya, peningkatan kadar Primogel mempercepat waktu hancur dan meningkatkan profil disolusi. Formula terbaik ditunjukkan oleh kombinasi PVP K-30 2% dan Primogel 4% (F3), yang menghasilkan tablet dengan waktu hancur tercepat dan disolusi tertinggi (>85% dalam 30 menit). Dengan demikian, kombinasi pengikat dan penghancur yang seimbang sangat penting untuk menghasilkan sediaan padat dengan mutu fisik dan performa pelepasan zat aktif yang optimal. -------- This study aims to determine the effect of varying concentrations of the binder PVP K-30 and the disintegrant Primogel (Sodium Starch Glycolate) on the physical properties of brazilin granules and the characteristics of the resulting tablets. The wet granulation method was employed using four formulas containing 40% brazilin isolate with different concentrations of PVP K-30 (2% and 4%) and Primogel (2% and 4%). Granule evaluations included moisture content, flow rate, compressibility, angle of repose, and particle size distribution. Tablet evaluations included weight uniformity, hardness, disintegration time, friability, and dissolution profile. The results demonstrated that variations in PVP K-30 and Primogel concentrations significantly influenced both granule and tablet characteristics. Increased PVP K-30 concentration enhanced tablet compactness and hardness but slowed down disintegration and dissolution. Conversely, a higher concentration of Primogel accelerated disintegration and improved the dissolution profile. The optimal formulation was achieved with the combination of 2% PVP K-30 and 4% Primogel (F3), which produced tablets with the fastest disintegration time and the highest dissolution rate (>85% in 30 minutes). Therefore, a balanced combination of binder and disintegrant is crucial for producing solid dosage forms with optimal physical quality and drug release performance.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Brazilin, PVP K-30, Primogel, granulasi basah, tablet, disolusi, pengaruh variasi pengikat dan penghancur. ------- Brazilin, PVP K-30, Primogel, wet granulation, tablet, dissolution, effect of binder and disintegrant variation.
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	20 Nov 2025 07:42
Last Modified:	20 Nov 2025 07:42
URI:	http://repository.stfi.ac.id/id/eprint/3547

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