ZAKIA RAHMAH, - (2025) FORMULASI SEDIAAN SAMPO EKSTRAK ETANOL DAUN ROSEMARY (Rosmanius officianalis) DAN DAUN MIMBA (Azadirachta indica Juss) DENGAN KOMBINASI SODIUM LAURYL ETHER SULFATE DAN COCAMIDOPROPYL BETAINE SEBAGAI SURFAKTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Ketombe merupakan masalah umum pada kulit kepala yang disebabkan oleh pertumbuhan jamur Malassezia furfur. Penggunaan bahan kimia sintetis dalam sampo antiketombe sering menimbulkan efek samping seperti iritasi kulit kepala dan rambut kering, sehingga diperlukan alternatif berbahan alami. Penelitian ini bertujuan untuk memformulasikan sediaan sampo antiketombe dari kombinasi ekstrak etanol daun rosemary (Rosmarinus officinalis) dan daun mimba (Azadirachta indica), dengan surfaktan Sodium Lauryl Ether Sulfate (SLES) dan Cocamidopropyl Betaine (CAPB). Ekstraksi dilakukan secara maserasi menggunakan etanol 96%, kemudian diuji aktivitas antijamurnya terhadap M. furfur menggunakan metode difusi cakram. Hasil menunjukkan ekstrak rosemary 2,25% dengan zona hambat sebesar (8,19±3,04 mm) ekstrak daun mimba (2,03±3,52 mm), sedangkan kombinasi ekstrak rosemary dan mimba (E2) memberikan zona hambat terbesar yaitu (7,23±1,57 mm) mendekati nilai kontrol positif ketokonazol (10,88±4,77 mm). Evaluasi sediaan meliputi organoleptik, pH, homogenitas, viskositas, tinggi busa. Stabilitas fisik diuji menggunakan cycling test selama 6 siklus. Kedua formulasi memenuhi persyaratan evaluasi sediaan dan stabil selama cycling test. Uji aktivitas antijamur menunjukan formula 2 menghasilkan zona hambat tertinggi (9,33±5,73 mm), diikuti formula 1 (9,31±4,84 mm). Kombinasi ekstrak rosemary dan mimba berpotensi sebagai bahan aktif antiketombe alami yang efektif dan aman untuk formulasi sampo herbal dengan aktivitas antijamur sedang. ------- Dandruffis a common scalp problem caused by the growth of the fungus Malassezia furfur. The use of synthetic chemicals in anti-dandruff shampoos often causes side effects such as scalp irritation and dry hair, so natural alternatives are needed. This study aims to formulate an anti-dandruff shampoo preparation from a combination of ethanol extracts of rosemary leaves (Rosmarinus officinalis) and neem leaves (Azadirachta indica), with surfactants Sodium Lauryl Ether Sulfate (SLES) and Cocamidopropyl Betaine (CAPB). Extraction was carried out by maceration using 96% ethanol, then tested for its antifungal activity against M. furfur using the disc diffusion method. The results showed that 2.25% rosemary extract had an inhibition zone of (8.19+3.04 mm) compared to neem leaf extract (2.03±3.52 mm). While the combination of rosemary and neem extract (1:2) produced the largest inhibition zone of (7.23±1.57 mm), comparable to the positive control ketoconazole (10.88±4.77 mm). Evaluation ofthe formulations included organoleptic properties, pH, homogeneity, viscosity, and foam height. Physical stability was tested using a cycling test for 6 cycles. Both formulations met the formulation evaluation requirements and were stable during the cycling test. Antifungal activity testing showed that formula 2 produced the highest inhibition zone (9.33±5.73 mт), followed by formula 1 (9.31±4.84 mm). The combination of rosemary and neет extracts has the potential to be an effective and safe natural anti-dandruff active ingredient for herbal shampoo formulations with moderate antifungal activity.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Rosemary, Mimba, Sampo Antiketombe, SLES, cocamidopropyl betaine. ------- Rosemary, Neem, Anti-dandruff Shampoo, SLES, Cocamidopropyl Betaine. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 20 Nov 2025 04:38 |
| Last Modified: | 20 Nov 2025 04:38 |
| URI: | http://repository.stfi.ac.id/id/eprint/3531 |
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