STUDI DISOLUSI BERBAGAI SEDIAAN PADAT ORAL PIROKSIKAM DAN KAJIAN CARA PENINGKATAN DISOLUSI

RARA ANNISA AZZAHRA, - (2025) STUDI DISOLUSI BERBAGAI SEDIAAN PADAT ORAL PIROKSIKAM DAN KAJIAN CARA PENINGKATAN DISOLUSI. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Piroksikam merupakan obat antiinflamasi nonsteroid (AINS) yang memiliki kelarutan rendah dalam air dan tergolong BCS kelas II, sehingga disolusi menjadi faktor pembatas utama dalam absorpsi oralnya. Penelitian ini bertujuan untuk mengetahui laju disolusi dan kadar berbagai sediaan tablet dan kapsul yang beredar di pasaran, mengevaluasi kesesuaiannya terhadap persyaratan mutu Farmakope Indonesia, serta melakukan kajian literatur mengenai metode peningkatan laju disolusi piroksikam. Penetapan kadar dilakukan menggunakan spektrofotometer UV-Vis pada panjang gelombang maksimum 349 nm, sedangkan uji disolusi dilakukan menggunakan alat disolusi tipe II (dayung) dan kecepatan rotasi 75 rpm untuk tablet serta tipe I (keranjang) dan kecepatan rotasi 50 rpm untuk kapsul. Media disolusi yang digunakan adalah HCl 0,01 N dan cairan lambung buatan LP (tanpa enzim) pH 1,2 dengan suhu 37 ± 0,5°C. Hasil penelitian menunjukkan bahwa sediaan tablet memiliki kadar 19,63 mg dan sediaan kapsul 21,21 mg, keduanya memenuhi persyaratan kadar sesuai Farmakope Indonesia. Namun, hasil uji disolusi menunjukkan bahwa tablet belum memenuhi syarat disolusi, sedangkan kapsul memenuhi persyaratan disolusi. Berdasarkan kajian literatur, metode yang dapat digunakan untuk meningkatkan disolusi piroksikam meliputi pembentukan kompleks inklusi dengan siklodekstrin, pembentukan dispersi padat, pembentukan garam piroksikam, dan pengembangan ko-kristal. ------ Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) with low aqueous solubility and is classified as a BCS Class II drug, therefore dissolution becomes the main rate-limiting step in its oral absorption. This study aims to determine the dissolution rate and assay of various marketed tablet and capsule dosage forms of piroxicam, to evaluate their compliance with the quality requirements of the Indonesian Pharmacopoeia, and to review literature on methods for improving the dissolution of piroxicam. The assay was performed using a UV-Vis spectrophotometer at a maximum wavelength of 349 nm, while the dissolution test was conducted using a type II (paddle) apparatus at 75 rpm for tablets and a type I (basket) apparatus at 50 rpm for capsules. The dissolution media used were 0,01 N HCl and simulated gastric fluid without enzymes (pH 1,2) maintained at 37 ± 0,5°C. The results showed that the tablet dosage form contained 19,63 mg of piroxicam and the capsule contained 21,21 mg, both meeting the assay requirements specified in the Indonesian Pharmacopoeia. However, the dissolution test results indicated that the tablet formulation did not meet the dissolution requirement, whereas the capsule formulation complied with the specification. Based on literature review, methods that can be used to increase the dissolution of piroxicam include the formation of inclusion complexes with cyclodextrin, the formation of solid dispersions, the formation of piroxicam salts, and the development of co-crystals.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Piroksikam, Tablet, Kapsul, Disolusi, Siklodekstrin. ----- Piroxicam, Tablet, Capsule, Dissolution, Cyclodextrin
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	20 Nov 2025 02:57
Last Modified:	20 Nov 2025 02:57
URI:	http://repository.stfi.ac.id/id/eprint/3519

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