CITRA MAWARNI AYU PUTRI, - (2025) UJI AKTIVITAS EKSTRAK AIR FREEZE DRY IKAN GABUS (Channa striata) TERHADAP PROSES PENYEMBUHAN LUKA PADA MENCIT JANTAN (Mus musculus). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Luka merupakan kondisi terputusnya jaringan kulit akibat kerusakan, sehingga fungsi kulit sebagai pelindung tubuh terganggu. Untuk mendukung dalam perbaikannya, dibutuhkan asupan protein seperti ikan gabus (Channa striata) yang kaya akan albumin. Tujuan penelitian ini untuk mengetahui aktivitas ekstrak air freeze dry ikan gabus dalam bentuk sediaan gel terhadap penyembuhan luka pada mencit jantan (Mus musculus) serta menentukan konsentrasi paling optimal. Penelitian ini terdiri atas lima kelompok perlakuan, yaitu kontrol normal (tanpa perlakuan), kontrol negatif (basis gel Na-CMC), kontrol positif (Bioskin Gel®), kelompok uji 1 (gel 4% ekstrak air freeze dry ikan gabus) dan kelompok uji 2 (8% gel ekstrak air freeze dry ikan gabus). Parameter yang diamati meliputi pengukuran diameter luka dan pemeriksaan histopatologi. Sementara data dianalisis menggunakan OneWay ANOVA dan uji lanjut post hoc Bonferroni. Hasil penelitian menunjukkan bahwa kelompok uji gel 4% memiliki rata-rata diameter luka lebih kecil (2,88 ± 0,65 mm) dibandingkan kelompok yang lain, dengan persentase penyembuhan lukanya mencapai 42,33 ± 13,05% dan terdapat perbedaan signifikan antar kelompok (p < 0,05). Pada hasil histopatologi, kelompok uji gel 4% menunjukkan angiogenesis lebih baik dan kelompok uji gel 8% menunjukkan epitelisasi lebih lengkap. Dengan demikian, konsentrasi 8% dianggap paling optimal dalam mendukung pembentukan jaringan kulit baru secara menyeluruh. ----- A wound is a condition in which the skin tissue is disrupted, causing impairment of its protective function for the body. To support the repair process, protein intake is needed, such as from snakehead fish (Channa striata), which is rich in albumin. This study aimed to determine the wound-healing activity of freeze-dried aqueous extract of snakehead fish in gel form on male mice (Mus musculus) and to find the most optimal concentration. The experiment consisted of five groups: normal control (no treatment), negative control (Na-CMC gel base), positive control (Bioskin Gel®), test group 1 (4% gel of freeze-dried aqueous extract of snakehead fish), and test group 2 (8% gel of freeze-dried aqueous extract of snakehead fish). Parameters observed included wound diameter and histopathological features. Data were analyzed using One-Way ANOVA and Bonferroni post hoc test. The 4% gel group had the smallest mean wound diameter (2.88 ± 0.65 mm) and the highest healing percentage (42.33 ± 13.05%), showing a significant difference (p < 0.05). Histopathological results showed better angiogenesis in the 4% gel group, while the 8% gel group exhibited more complete epithelialization. Therefore, the 8% concentration was considered the most optimal for promoting full tissue regeneration.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Ikan Gabus, Protein, Albumin, Diameter Luka, Histopatologi. ----- Snakehead Fish, Protein, Albumin, Wound Diameter, Histopathology |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 19 Nov 2025 02:43 |
| Last Modified: | 19 Nov 2025 02:43 |
| URI: | http://repository.stfi.ac.id/id/eprint/3487 |
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