FORMULASI DAN KARAKTERISASI NANOEMULSI ISOLAT KURKUMIN MENGGUNAKAN SIMPLEX LATTICE DESIGN

ARYANI NURJANAH, - (2025) FORMULASI DAN KARAKTERISASI NANOEMULSI ISOLAT KURKUMIN MENGGUNAKAN SIMPLEX LATTICE DESIGN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Penuaan kulit merupakan proses multifaktorial ditandai dengan kerutan, elastisitas kulit yang berkurang, hiperpigmentasi, dan tekstur kulit yang kasar. Kurkumin berpotensi untuk mengurangi penuaan kulit, namun memiliki penetrasi yang rendah ke dalam kulit, sehingga dibutuhkan sistem penghantaran nanoemulsi. Penelitian ini bertujuan mengembangkan formula nanoemulsi mengandung isolat kurkumin yang optimal menggunakan simplex lattice design dengan tiga faktor, yaitu minyak cengkeh (5-10%), PEG-40 HCO (10-20%) dan propilen glikol (10-15%) dengan respon persen transmitan. Berdasarkan hasil analisis simplex lattice design didapatkan formula optimum yaitu minyak cengkeh 5%, PEG-40 HCO 17,531% dan propilen glikol 12,469% dengan nilai desirability sebesar 1,000. Nanoemulsi yang dihasilkan memiliki pH 5,29 ± 0,009, viskositas 24,67 ± 0,471 cP, hasil sentrifugasi dengan tidak terjadi creaming dan pemisahan fase namun terdapat sedikit pengendapan, persen transmitan 99,535 ± 0,260%, ukuran doplet 17,8 ± 0,7 nm, PDI 0,133 ± 0,021, dan zeta potensial -31,6 mV. Uji penetrasi kulit secara in vitro menunjukkan nanoemulsi kurkumin memiliki kemampuan penetrasi yang lebih baik dibandingkan emulsi kurkumin dengan persentase difusi sebesar 87,795% selama 240 menit. Hasil penelitian ini didapatkan formula optimum nanoemulsi isolat kurkumin dengan karakteristik fisik yang baik. ------- Skin aging is a multifactorial process characterized by wrinkles, reduced elasticity, hyperpigmentation, and rough skin texture. Curcumin has the potential to reduce skin aging; however, it has poor skin penetration, thus a nanoemulsion delivery system is required. This study aimed to develop an optimal nanoemulsion formulation containing curcumin isolate using a simplex lattice design with three factors, namely clove oil (5–10%), PEG-40 HCO (10–20%), and propylene glycol (10–15%), with percent transmittance as the response. Based on simplex lattice design analysis, the optimum formula consisted of 5% clove oil, 17,531% PEG-40 HCO, and 12,469% propylene glycol with a desirability value of 1,000. The resulting nanoemulsion had a pH of 5,29 ± 0,009, viscosity of 24,67 ± 0,471 cP, centrifugation results with no creaming or phase separation but slight precipitation, percent transmittance of 99,535 ± 0,260%, droplet size of 17,8 ± 0,7 nm, PDI of 0,133 ± 0,021, and zeta potential of −31,6 mV. In vitro skin penetration testing showed that the curcumin nanoemulsion exhibited better penetration ability than the curcumin emulsion, with a diffusion percentage of 87,795% within 240 minutes. The results indicated that the optimum curcumin isolate nanoemulsion formula possessed good physical characteristics.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Nanoemulsi, Kurkumin, Simplex lattice design, Antiaging, Penetrasi kulit. ----- Nanoemulsion, Curcumin, Simplex lattice design, Antiaging, Skin penetration
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	19 Nov 2025 01:45
Last Modified:	19 Nov 2025 01:45
URI:	http://repository.stfi.ac.id/id/eprint/3476

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