FORMULASI MASKER CLAY ETIL p-METOKSISINAMAT (EPMS) SEBAGAI ANTIJERAWAT DENGAN DESAIN BOX-BEHNKEN

ADIT ANDRIYANNTO, - (2025) FORMULASI MASKER CLAY ETIL p-METOKSISINAMAT (EPMS) SEBAGAI ANTIJERAWAT DENGAN DESAIN BOX-BEHNKEN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

	Text S_PSSF_A242001_Title.pdf Download (689kB)
	Text S_PSSF_A242001_Chapter1.pdf Restricted to Repository staff only Download (233kB)
	Text S_PSSF_A242001_Chapter2.pdf Restricted to Repository staff only Download (398kB)
	Text S_PSSF_A242001_Chapter3.pdf Restricted to Repository staff only Download (330kB)
	Text S_PSSF_A242001_Chapter4.pdf Restricted to Repository staff only Download (806kB)
	Text S_PSSF_A242001_Chapter5.pdf Restricted to Repository staff only Download (245kB)
	Text S_PSSF_A242001_Appendix.pdf Restricted to Repository staff only Download (2MB)

Abstract

Jerawat (acne vulgaris) merupakan salah satu penyakit kulit yang umum terjadi pada 80–85% populasi dewasa muda atau remaja di Indonesia. Etil pmetoksisinamat (EPMS) adalah senyawa alami utama dari rimpang kencur (Kaempferia galanga L.) dengan konsentrasi hambat minimum (KHM) 1,2% terhadap Propionibacterium acnes, bakteri penyebab jerawat. Dalam upaya meningkatkan aktivitas dan kemudahan penggunaan, dikembangkan sediaan masker clay sebagai sistem penghantaran yang inovatif. Penelitian ini bertujuan memperoleh formula optimum masker clay menggunakan metode Desain BoxBehnken dengan tiga variabel bebas, yaitu kaolin (15–30% b/b), bentonit (1–2% b/b), dan xanthan gum (0,5–1% b/b). Variabel terikat meliputi pH, viskositas, dan waktu mengering. Hasil analisis menghasilkan formula optimum dengan kaolin 26,925% b/b, bentonit 1,808% b/b, dan xanthan gum 0,854% b/b dengan desirabilitas 1,000. Evaluasi menunjukkan pH 7,560 ± 0,0899, viskositas 20583,33 ± 650,85 mPa·s, waktu mengering 25.58 ± 1.36 menit, daya sebar 4,038 ± 0,096 cm dan daya lekat 8,80 ± 1,018 detik. Uji antibakteri menghasilkan zona hambat sedang sebesar 6,969 ± 0,896 mm, lebih besar dibandingkan zat murninya. Disimpulkan bahwa masker clay formula optimum memiliki karakteristik fisik yang baik serta aktivitas antibakteri, sehingga berpotensi digunakan sebagai sediaan topikal untuk terapi jerawat. ------ Acne vulgaris is a common skin disorder affecting 80–85% of adolescents and young adults in Indonesia. Ethyl p-methoxycinnamate (EPMC), the major compound of Kaempferia galanga L. rhizomes, shows antibacterial activity with a minimum inhibitory concentration (MIC) of 1.2% against Propionibacterium acnes, the main acne-causing bacterium. To improve its activity and ease of use, a clay mask was developed as an innovative topical delivery system. This study aimed to obtain the optimum clay mask formula using the Box-Behnken Design with three independent variables: kaolin (15–30% w/w), bentonite (1–2% w/w), and xanthan gum (0.5–1% w/w). The dependent variables observed were pH, viscosity, and drying time. The analysis produced an optimum formula consisting of 26.925% w/w kaolin, 1.808% w/w bentonite, and 0.854% w/w xanthan gum with a desirability value of 1.000. Evaluation of this formula showed a pH of 7.560 ± 0.0899, viscosity of 20583.33 ± 650.85 mPa·s, drying time of 25.58 ± 1.36 minutes, spreadability of 4.038 ± 0.096 cm, and adhesion of 8.80 ± 1.018 seconds. Antibacterial testing revealed a moderate inhibition zone of 6.969 ± 0.896 mm, greater than that of the pure compound. In conclusion, the optimized clay mask exhibited good physical characteristics and antibacterial activity, supporting its potential as a topical formulation for acne therapy.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Masker Clay, Etil p-metoksisinamat, Desain Box-Behnken, Propionibacterium Acnes. ------ Clay Mask, Ethyl p-Methoxycinnamate, Box-Behnken Design Propionibacterium acnes.
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	17 Nov 2025 07:30
Last Modified:	17 Nov 2025 07:30
URI:	http://repository.stfi.ac.id/id/eprint/3467

Actions (login required)

View Item