MUHAMMAD DIFO ANANDA, - (2025) MODIFIKASI ETIL P-METOKSISINAMAT-ASAM BENZOAT DENGAN METODE NANOCONFINED COAMORPHOUS. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Etil p-Metoksisinamat (EPMS) merupakan senyawa bioaktif dari Kaempferia galanga L. dengan potensi farmakologis tinggi, namun penggunaannya terbatas karena kelarutan dan disolusi yang sangat rendah. Penelitian ini bertujuan untuk membentuk sistem NCA EPMS–asam benzoat serta mengevaluasi perbaikan profil kelarutan dan disolusinya. Metode yang digunakan adalah solvent evaporation untuk menghasilkan sistem biner EPMS–asam benzoat (1:1 stoikiometri), yang selanjutnya dimuat ke dalam mesopori silika nanopartikel (sistem biner:MSN 3:7) guna memperoleh NCA. Karakterisasi dilakukan dengan FT-IR, dan evaluasi berupa penetapan kadar, kelarutan dalam air serta disolusi menggunakan media simulasi gastrointestinal (pH 1,2; 4,5; 6,8). Hasil karakterisasi FT-IR menunjukkan adanya pergeseran pita serapan C=O dan –OH yang menegaskan terbentuknya interaksi ikatan hidrogen, sehingga EPMS berhasil dibentuk menjadi sistem NCA tanpa menghasilkan senyawa baru. Hasil penetapan kadar menunjukkan bahwa kandungan EPMS dalam NCA sebesar 9,5%. Uji kelarutan menunjukkan peningkatan 1,05 kali pada NCA (38,275 mg/L) dibandingkan EPMS murni (36,364 mg/L). Uji disolusi memperlihatkan peningkatan signifikan, yaitu 3,96 kali pada pH 1,2; 3,84 kali pada pH 4,5; 4,31 kali pada pH 6,8. Berdasarkan penelitian ini, dapat disimpulkan bahwa sistem NCA EPMS–asam benzoat dapat dibentuk serta terbukti mampu meningkatkan kelarutan dan profil disolusi sehingga berpotensi meningkatkan bioavailabilitas oral EPMS. ----- Ethyl p-Methoxycinnamate (EPMC) is a bioactive compound from Kaempferia galanga L. with high pharmacological potential, but its application is limited due to very low solubility and dissolution. This study aimed to develop an EPMC– benzoic acid nanoconfined coamorphous (NCA) system and evaluate its solubility, dissolution, and content assay. The binary system of EPMC–benzoic acid (1:1 stoichiometry) was prepared by solvent evaporation and subsequently loaded into mesoporous silica nanoparticles (binary system:MSN 3:7) to obtain NCA. Characterization was conducted using FT-IR, while evaluations included assay of content, aqueous solubility, and dissolution in gastrointestinal simulation media (pH 1.2, 4.5, and 6.8). FT-IR results showed shifts in the C=O and –OH absorption bands, confirming hydrogen bond interactions and indicating successful conversion of EPMC into an NCA system without the formation of new compounds. The content assay showed that the EPMC content in NCA was 9.5%. The solubility test demonstrated a 1.05-fold increase for NCA (38.275 mg/L) compared to pure EPMC (36.364 mg/L). Dissolution studies revealed significant improvements, with 3.96-fold at pH 1.2, 3.84-fold at pH 4.5, and 4.31-fold at pH 6.8. In conclusion, the EPMC–benzoic acid NCA system was successfully developed and proven to enhance solubility and dissolution, suggesting its potential to improve the oral bioavailability of EPMC.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Asam benzoat, disolusi, etil p-metoksisinamat, kelarutan, nanoconfined coamorphous. ------ Benzoic acid, dissolution, ethyl p-methoxycinnamate, nanoconfined coamorphous, solubility. |
| Subjects: | Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 17 Nov 2025 06:30 |
| Last Modified: | 17 Nov 2025 06:30 |
| URI: | http://repository.stfi.ac.id/id/eprint/3460 |
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