OPTIMASI FORMULA SERUM ANTI ACNE BERBASIS ETIL pMETOKSISINAMAT DENGAN VARIASI SURFAKTAN DAN KOSURFAKTAN

SOFI DUROTUN NAFISAH, - (2025) OPTIMASI FORMULA SERUM ANTI ACNE BERBASIS ETIL pMETOKSISINAMAT DENGAN VARIASI SURFAKTAN DAN KOSURFAKTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Etil p-metoksisinamat adalah senyawa aktif dari rimpang kencur (Kaempferia galanga Linn.). yang memiliki potensi sebagai tabir surya, anti-acne, dan pencerah kulit. Namun, kestabilannya dalam sediaan berbasis air seperti serum masih rendah karena mudah mengalami hidrolisis dan oksidasi. Penelitian ini bertujuan untuk mengevaluasi stabilitas fisik dan kimia serum etil p-metoksisinamat dengan variasi konsentrasi polysorbate 80 sebagai surfaktan dan propilenglikol sebagai kosurfaktan. Penelitian dilakukan terhadap tiga formula serum, yaitu Formula 1 (9:6,3), Formula 2 (8:5,5), dan Formula 3 (6,5:5,5). Evaluasi meliputi parameter fisik (organoleptis, pH, viskositas, daya sebar, daya lekat) serta kadar etil pmetoksisinamat menggunakan spektrofotometri UV-Vis. Hasil menunjukkan seluruh formula memiliki kestabilan fisik baik, dengan pH 6,16–6,34, viskositas ±300 mPas, daya sebar ±7 cm, dan daya lekat tertinggi pada Formula 1 (22,94 detik). Uji kadar Etil p-metoksisinamat menunjukkan Formula 3 memiliki efisiensi inkorporasi tertinggi sebesar 97,41%. Formula 3 direkomendasikan sebagai formula paling optimal karena menunjukkan kestabilan fisik yang baik dan efisiensi inkorporasi senyawa aktif yang tinggi, yang mencerminkan kestabilan kimia yang lebih baik. ----- Ethyl p-methoxycinnamate is an active compound derived from the rhizome of Kaempferia galanga Linn., known for its potential as a sunscreen agent, anti-acne, and skin-brightening ingredient. However, its application in water-based formulations such as serums is limited due to its low chemical stability, particularly susceptibility to hydrolysis and oxidation. This study aimed to evaluate the physical and chemical stability of ethyl p-methoxycinnamate -based serum with varying concentrations of polysorbate 80 as a surfactant and propyleneglycol as a cosurfactant. Three serum formulations were developed: Formula 1 (9:6.3), Formula 2 (8:5.5), and Formula 3 (6.5:5.5). Evaluation included physical parameters (organoleptic properties, pH, viscosity, spreadability, and adhesion) and determination of ethyl p-methoxycinnamate content using UV-Vis spectrophotometry. Results showed that all formulations exhibited good physical stability, with pH ranging from 6.16 to 6.34, viscosity around 300 mPas, and spreadability of approximately 7 cm. Formula 1 showed the highest adhesion (22.94 seconds), while Formula 3 demonstrated the highest incorporation efficiency of Ethyl p-methoxycinnamate at 97.41%. It is concluded that Formula 3 is the most optimal formulation, providing both good physical stability and high active compound incorporation, indicating better chemical stability.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Etil p-metoksisinamat, stabilitas, serum, surfaktan, kosurfaktan. ----- Ethyl p-methoxycinnamate, stability, serum, surfactant, cosurfactant.
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	10 Sep 2025 02:21
Last Modified:	10 Sep 2025 02:21
URI:	http://repository.stfi.ac.id/id/eprint/2784

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