PENGUJIAN STABILITAS DIPERCEPAT ISOLAT KURKUMIN

SILFIA NURA’IN, - (2023) PENGUJIAN STABILITAS DIPERCEPAT ISOLAT KURKUMIN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Isolat kurkumin yang berhasil diproduksi Sekolah Tinggi Farmasi Indonesia (STFI) dalam skala besar akan digunakan menjadi bahan baku obat dalam industri farmasi. Sehingga dalam memastikan mutu hasil isolat perlu dilakukan pengujian kualitas, diantaranya pengujian stabilitas umur simpan dari isolat kurkumin produk STFI. Penelitian ini dilakukan untuk mengetahui bagaimana profil validasi dari metode yang digunakan dalam pengujian stabilitas dipercepat dan berapa lama waktu umur simpan dari isolat kurkumin. Validasi metode pengukuran menggunakan intrumen Kromatografi Cair Kinerja Tinggi (KCKT), kemudian dilakukan uji stabilitas dipercepat selama 6 bulan dengan frekuensi pengujian bulan ke- 0, 3, dan 6 bulan pada climatic chamber dengan suhu pengujian yang dilakukan 40°C ± 2°C dan kelembapan 75% ± 5% RH. Hasil dari penelitian validasi metode didapatkan profil validasi standar memenuhi syarat serta hasil perhitungan pengujian stabilitas dipercepat isolat kurkumin produk STFI memiliki waktu umur simpan selama 6 tahun 3 bulan 25 hari. --- Curcumin isolate successfully produced by the Indonesian College of Pharmacy (STFI) on a large scale will be used as raw material for drugs in the pharmaceutical industry. So that in ensuring the quality of the isolate results, quality testing needs to be carried out, including testing the shelf life stability of the curcumin isolate produced by STFI. This study was conducted to determine how the validation profile of the method used in accelerated stability testing and how long the shelf life of curcumin isolate. Validation of the measurement method using High Performance Liquid Chromatography (HPLC) instruments, then accelerated stability testing was carried out for 6 months with a testing frequency of months 0, 3, and 6 months in a climatic chamber with a testing temperature of 40 ° C ± 2 ° C and humidity of 75% ± 5% RH. The results of the method validation study obtained a qualified standard validation profile and the results of the accelerated stability testing calculation of STFI product curcumin isolate have a shelf life of 6 years 3 months 25 days.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Isolat kurkumin, KCKT, uji stabilitas dipercepat, validasi metode analisis, umur simpan. Curcumin isolate, HPLC, accelerated stability test, analytical method validation, shelf life.
Subjects:	Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	21 Jun 2024 04:06
Last Modified:	21 Jun 2024 04:06
URI:	http://repository.stfi.ac.id/id/eprint/278

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