SALMA RUHAIMATUL BADARI, - (2025) FORMULASI ACNE PATCH ETIL p-METOKSISINAMAT SEBAGAI ANTI JERAWAT MENGGUNAKAN BOX-BEHNKEN DESIGN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Acne vulgaris (jerawat) merupakan penyakit umum yang dialami oleh remaja hingga dewasa dengan prevalensi sebesar 80–85% di Indonesia. Senyawa etil pmetoksisinamat yang berasal dari rimpang kencur (Kaempferia galanga L.) telah terbukti memiliki aktivitas antibakteri terhadap Propionibacterium acnes sebagai penyebab jerawat, dengan konsentrasi hambat minimum (KHM) sebesar 1,2%. Untuk meningkatkan efektivitas dan kemudahan penggunaan, dikembangkan sediaan acne patch sebagai bentuk topikal yang inovatif. Penelitian ini bertujuan untuk memperoleh formula acne patch yang optimal menggunakan metode BoxBehnken Design dengan tiga variabel bebas, yaitu konsentrasi HPMC (3–6%), PVP (1–2%), dan lama pengadukan (15–30 menit). Variabel terikat yang diamati meliputi ketebalan (mm), daya lipat (lipatan), dan daya lekat (detik). Patch dibuat dengan melarutkan polimer dalam pelarut, kemudian dikeringkan. Formula optimum yang diperoleh terdiri atas HPMC 3,213%, PVP 1,022%, dan lama pengadukan 17,535 menit, dengan nilai desirabilitas 1,000. Evaluasi menunjukkan bahwa sediaan memiliki ketebalan 0,2 ± 0 mm, daya lekat 810,667 ± 20,133 detik, daya lipat 207,333 ± 2,517 kali, pH 5,68 ± 0,168, dan kelembapan 29,4 ± 2,623%. Uji aktivitas antibakteri menunjukkan zona hambat lemah 6,6 ± 0,736 mm, lebih besar dibandingkan zat murninya. Dari hasil penelitian ini, dapat disimpulkan bahwa acne patch memiliki karakteristik fisik dan aktivitas antibakteri yang baik sebagai terapi topikal, meskipun kadar kelembapan masih perlu disesuaikan agar memenuhi syarat stabilitas. ---- Acne vulgaris was a common skin disorder affecting adolescents and adults, with a prevalence of 80–85% in Indonesia. Ethyl p-methoxycinnamate, a compound derived from Kaempferia galanga L. rhizome, had demonstrated antibacterial activity against Propionibacterium acnes, with a minimum inhibitory concentration (MIC) of 1.2%. To improve effectiveness and ease of use, an acne patch was developed as an innovative topical dosage form. This study aimed to obtain an optimal acne patch formula using the Box–Behnken Design with three independent variables: HPMC concentration (3–6%), PVP concentration (1–2%), and stirring time (15–30 minutes). The dependent variables were thickness (mm), folding endurance (folds), and adhesion time (seconds). The patch was prepared by dissolving polymers in a solvent and drying the mixture. The optimal formula consisted of 3.213% HPMC, 1.022% PVP, and 17.535 minutes of stirring time, with a desirability value of 1.000. The formulation showed a thickness of 0.2 ± 0 mm, adhesion time of 810.667 ± 20.133 seconds, folding endurance of 207.333 ± 2.517 folds, pH of 5.68 ± 0.168, and moisture content of 29.4 ± 2.623%. Antibacterial activity showed an inhibition zone of 6.6 ± 0.736 mm, greater than the pure compound. These results indicated that the acne patch had good physical characteristics and antibacterial activity for topical therapy, although its moisture content needed adjustment to meet stability requirements.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Acne patch, etil p-metoksisinamat, Box-Behnken Design, HPMC, PVP, Propionibacterium Acnes. ------ Acne patch, . Ethyl p-methoxycinnamate, Box-Behnken Design, HPMC, PVP, Propionibacterium Acnes. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 09 Sep 2025 02:30 |
| Last Modified: | 09 Sep 2025 02:30 |
| URI: | http://repository.stfi.ac.id/id/eprint/2775 |
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