UJI STABILITAS KELARUTAN NANOCONFINED COAMORPHOUS (NCA) ETIL p-METOKSISINAMAT (EPMS) ASAL RIMPANG KENCUR (Kaempferiae galanga L.)

RIZKY AKBAR SANJAYA, - (2023) UJI STABILITAS KELARUTAN NANOCONFINED COAMORPHOUS (NCA) ETIL p-METOKSISINAMAT (EPMS) ASAL RIMPANG KENCUR (Kaempferiae galanga L.). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Kelarutan merupakan salah satu hal penting dalam menentukan bioavailibilitas suatu obat. Etil p-metoksisinamat (EPMS) memiliki kelarutan dalam air sebesar 0,0301 mg/mL atau praktis tidak larut air. Tujuan penelitian ini adalah untuk melakukan upaya dalam meningkatkan kelarutan EPMS dengan stabilitas yang baik. Nanoconfinced Coamorphous (NCA) merupakan salah satu cara yang dapat berpotensi dalam upaya meningkatkan kelarutan. NCA adalah bentuk penggabungan antara co-former dengan zat aktif, yang nantinya dari penggabungan tersebut dimasukkan ke dalam mesoporous silica nanopartikel (MSN) dengan rentang ukuran pori sebesar 2-50 nm, sehingga dengan penggabungan tersebut MSN dapat menjaga stabilitas kelarutan. Metode penelitian yang dilakukan uji stabilitas kelarutan NCA EPMS pada suhu 40˚C dengan kelembaban 75% dalam climatic chamber dengan kurun waktu 3 bulan. Sampel dilakukan pengukuran kelarutan pada masa sebelum penyimpanan, 1 bulan, 2 bulan, dan 3 bulan penyimpanan menggunakan alat spektrofotometer Uv-Vis. Hasil penelitian menunjukan adanya perbedaan stabilitas dari setiap sampel uji, stabilitas yang baik diperoleh pada sampel NCA SE EPMS nikotinamid dan NCA EPMS nikotinamid. Berdasarkan penelitian ini, kesimpulan yang diperoleh adalah NCA memiliki potensi dalam menjaga stabilitas kelarutan EPMS dalam waktu 3 bulan penelitian. --- Solubility is one of the important things in determining the bioavailability of a drug. Ethyl p-methoxycinnamate (EPMS) has a water solubility of 0.0301 mg/mL or is practically water insoluble. The purpose of this study was to make efforts in improving the solubility of EPMS with good stability. Nanoconfinced Coamorphous (NCA) is one way that can potentially increase solubility. NCA is a form of merger between co-former and active substance, which later from the merger is inserted into mesoporous silica nanoparticle (MSN) with a pore size range of 2-50 nm, so that with the merger MSN can maintain solubility stability. The research method was carried out by testing the solubility stability of NCA EPMS at 40 ° C with 75% humidity in the climatic chamber with a period of 3 months. Samples were measured for solubility before storage, 1 month, 2 months, and 3 months of storage using a Uv-Vis spectrophotometer. The results showed a difference in stability from each test sample, good stability was obtained in samples of NCA SE EPMS nicotinamide and NCA EPMS nicotinamide. Based on this study, the conclusion obtained is that NCA has the potential to maintain the stability of EPMS solubility within 3 months of research.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Kelarutan, Etil p-metoksisinamat (EPMS), Nanoconfined Coamorphous (NCA), Stabilitas. Solubility, Ethyl p-methoxycinnamate (EPMS), Nanoconfined Coamorphous (NCA), Stability.
Subjects:	R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	21 Jun 2024 03:57
Last Modified:	21 Jun 2024 03:57
URI:	http://repository.stfi.ac.id/id/eprint/277

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