OPTIMASI METODE PEMBUATAN NANOEMULSI ISOLAT KURKUMIN 95% DARI TANAMAN KUNYIT (Curcuma Domestica Val)

SUMARTIN LINDA SUPRAPTI, - (2023) OPTIMASI METODE PEMBUATAN NANOEMULSI ISOLAT KURKUMIN 95% DARI TANAMAN KUNYIT (Curcuma Domestica Val). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Isolat Kurkumin 95% adalah senyawa pada tanaman kunyit (Curcuma Domestica Val) yang merupakan campuran kurkuminoid desmetoksikurkumin dan bisdesmetoksikurkumin. Kurkumin memiliki rumus molekul C21H20O6, berfungsi sebagai antioksidan, antiinflamasi, serta antikanker, merupakan senyawa polifenol flavonoid tidak larut air tapi larut etanol, dimetil sulfoksida, dan aseton, namun bioavailabilitasnya rendah. Penelitian ini bertujuan mendapatkan metode pembuatan nanoemulsi isolat kurkumin 95% dengan stabilitas yang baik menggunakan Self-Nanoemulsifying Drug Delivery System (SNEDDS). Metode optimasi dilakukan pengadukan konvensional dan menggunakan mixer IKA dengan 5 variasi kecepatan pengadukan (rpm) berbeda. Formula terdiri dari isolat Kurkumin 95% sebagai zat aktif, minyak kelapa murni sebagai fase minyak, sukrosa monoester 1750 sebagai surfaktan, dan gliserol sebagai kosurfaktan. Hasil karakterisasi menunjukkan metode pengadukan mixer IKA kecepatan 1000 rpm selama 15 menit pada suhu 50°C menghasilkan nanoemulsi dengan kualitas organoleptis dan stabilitas yang optimal, pH sesuai dengan stabilitas isolat Kurkumin 95%, indeks bias rendah, persen transmitan jernih, ukuran partikel nanoemulsi 318±191 nm, indeks polidispersitas 0,433, dan zeta potensial -48,2 mV. Kesimpulan yang dapat diperoleh adalah nanoemulsi isolat Kurkumin 95% memiliki stabilitas yang baik dengan metode pengadukan 1000 rpm. --- Curcumin Isolate 95% is a compound in the turmeric plant (Curcuma Domestica Val) which is a mixture of curcuminoids desmetoxicurkumin and bisdesmetoxicurkumin. Curcumin has the molecular formula C21H20O6, functions as an antioxidant, anti-inflammatory, and anticancer, is a polyphenol flavonoid compound that is not water-soluble but soluble ethanol, dimethyl sulfoxide, and acetone, but its bioavailability is low. This study aims to obtain a method of making 95% curcumin isolate nanoemulsion with good stability using Self Nanoemulsifying Drug Delivery System (SNEDDS). The optimization method is carried out conventional stirring and using an IKA mixer with 5 different variations in stirring speed (rpm). The formula consists of 95% curcumin isolate as the active substance, virgin coconut oil as the oil phase, sucrose monoester 1750 as surfactant, and glycerol as cosurfactant. The characterization results showed that the stirring method of the IKA mixer at a speed of 1000 rpm for 15 minutes at a temperature of 50 °C produced nanoemulsions with optimal organoleptical quality and stability, pH according to the stability of curcumin isolates of 95%, low refractive index, clear transmittance percent, nanoemulsion particle size 318±191 nm, polydispersity index 0.433, and zeta potential -48.2 mV. The conclusion that can be obtained is that the nanoemulsion of 95% curcumin isolate has good stability with the 1000 rpm stirring method.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Isolat kurkumin 95%, nanoemulsi, formula, karakterisasi. curcumin 95%, nanoemulsion, formula, characterization.
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	20 Jun 2024 08:27
Last Modified:	20 Jun 2024 08:27
URI:	http://repository.stfi.ac.id/id/eprint/260

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