Anti-Inflammatory Activity of Artocarpus altilis (Parkinson) Fosberg in Wistar Male Rats

HESTI RIASARI, - (2019) Anti-Inflammatory Activity of Artocarpus altilis (Parkinson) Fosberg in Wistar Male Rats. Pharmacology and Clinical Pharmacy Research, 4 (1). pp. 22-26. ISSN 2527-7332

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Abstract

Inflammation is a local reaction in vascular tissue characterized by several symptoms, e.g., swelling, redness, and pain. Indonesia is one of the countries with high biodiversity, including traditional medicinal plants. Artocarpus altilis is one the plants that is widely used to treat inflammation. There is limited information on biological activity of A. altilis. This study was performed to evaluate anti-inflammatory properties of A. altilis detached and attached leaves in Wistar male rats. A. altilis was extracted using soxhlet method at 67.4 0C with methanol solvent. Inflammation was induced by the administration of car- rageenan to the rats paw. Subsequently, the extract of A. altilis were orally administered. The edema were measured using plethysmometer for 6 hours. We found that there were differences in anti-inflammatory activity between detached and attached leaves. The in- hibition of edema in attached leaves were 50% and 53.33% for the concentration of 50 mg and 100 mg, respectively. The greater inhibiton was observed in the detached leaves, with 73.33% and 76.67% inhibition, for the concentration of 50 mg and 100 mg, respec- tively. Nevertheless, the inhibition percentage was still below diclofenac sodium as a positive control (83.33%). In conclusion, A. altilis leaves extracts showed good anti-in- flammatory properties and has the potential for development of anti-inflammatory drug.

Item Type:	Article
Uncontrolled Keywords:	Artocarpus altilis, carageenan, inflammation, edema
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Lembaga Penelitian dan Pengabdian Masyarakat > Publikasi Penelitian
Depositing User:	pustakawan - -
Date Deposited:	29 Feb 2024 08:42
Last Modified:	04 Jul 2024 08:05
URI:	http://repository.stfi.ac.id/id/eprint/148

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