Comparison of Anti-Inflammatory Activity between Fermented and Dried Breadfruit Leaves Extract (Artocarpus Altilis)

HESTI RIASARI, - (2018) Comparison of Anti-Inflammatory Activity between Fermented and Dried Breadfruit Leaves Extract (Artocarpus Altilis). Pharmacology and Clinical Pharmacy Research, 3 (3). pp. 72-75. ISSN 2527-7332

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Abstract

Breadfruit leaves (Artocarpus altilis) have been empirically used to treat inflammation. Bio- synthesis process such as fermentation can possibly changes the composition of secondary metabolites in breadfruit leaves. The aim of this study was to compare the anti-inflammatory activity between fermented and natural-dried breadfruit leaves extract. Fermented and dried breadfruit leaves were extracted with soxhlet device using methanol solvent. The anti-in- flammatory activity of both extracts were evaluated using carrageenan (1% w/v) foot edema model of inflammation in male Wistar rats. The edema was measured with plethysmometer every 1 hour for 6 hours. The results showed that both extracts exhibited anti-inflammatory activity. 50 mg and 100 mg fermented leaves extracts exhibited 37.17% and 71.82% inhibi- tion, while the same concentrations of dried extract exhibited 39.50% and 57.72%, inhibiton respectively. In conclusion, the best anti-inflammatory activity was shown by fermented breadfruit leaves extract.

Item Type:	Article
Uncontrolled Keywords:	Artocarpus altilis, anti-inflammatory, breadfruit, fermentation
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	Lembaga Penelitian dan Pengabdian Masyarakat > Publikasi Penelitian
Depositing User:	pustakawan - -
Date Deposited:	29 Feb 2024 08:34
Last Modified:	04 Jul 2024 08:06
URI:	http://repository.stfi.ac.id/id/eprint/145

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