VIDYA PUTRI AYUNINGTYAS, - (2020) PENGARUH WAKTU DAN SUHU PENYIMPANAN TERHADAP KADAR AMOKSISILIN DAN ASAM KLAVULANAT DARI PRODUK RUAHAN (BULK) SIRUP KERING CO-AMOXICLAV. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Co-Amoxiclav merupakan antibiotik kombinasi antara amoksisilin dan asam klavulanat yang digunakan untuk mengatasi infeksi akibat bakteri yang sudah resisten terhadap amoksisilin tunggal. Amoksisilin dan asam klavulanat memiliki gugus cincin β-laktam yang mudah terhidrolisis jika kondisi penyimpanan tidak sesuai. Untuk itu dilakukan monitoring kadar amoksisilin dan asam klavulanat pada produk ruahan saat proses penyimpanan selama proses produksi berlangsung. Waktu dan suhu penyimpanan mempengaruhi penurunan kadar zat aktif dalam produk ruahan. Penentuan kadar dilakukan dengan metode KCKT (Kromatografi Cair Kinerja Tinggi) dengan fase gerak metanol : NaH2PO4 0,05 M (10:90) dengan fase diam kolom inertsil ODS 4 ukuran 150 x 4,6 mm 5 µm, laju alir 1,0 mL/menit dengan volume injek 20 µl pada panjang gelombang 220 nm. Sampel produk ruahan ini disimpan pada suhu chiller (2-8°C), suhu AC 24 jam (16-25°C) dan suhu ambient (< 30°C) selama 12 hari dengan waktu pengujian pada hari ke-0, 4, 8 dan 12. Penurunan kadar amoksisilin dan asam klavulanat yang paling signifikan terjadi pada suhu ambient (< 30°C), sedangkan kondisi penyimpanan yang paling stabil terhadap kadar amoksisilin dan asam klavulanat yaitu pada suhu chiller (2-8°C). Lama penyimpanan produk ruahan yang disarankan tidak lebih dari 4 hari. ---- Co-Amoxiclav is a combination antibiotic of amoxicillin and clavulanic acid which is used to treat infections caused by bacteria that are resistant to amoxicillin. Amoxicillin and clavulanic acid have β-lactam ring groups which are easily hydrolyzed if storage conditions are not suitable. For this reason, monitoring of amoxicillin and clavulanic acid levels in bulk products during the storage process during the production process is carried out. Storage time and temperature affect the decrease in the levels of active substances in bulk products. Determination of concentration was carried out by the HPLC method (High Performance Liquid Chromatography) with a mobile phase of methanol: NaH2PO4 0.05 M (10:90) with the stationary phase of the inertsil column ODS 4 size 150 x 4.6 mm 5 µm, flow rate 1.0 mL. / minute with an injection volume of 20 µl at a wavelength of 220 nm. These bulk product samples were stored at chiller temperature (2-8 ° C), 24-hour AC temperature (16-25 ° C) and ambient temperature (<30 ° C) for 12 days with testing time on days 0, 4, 8 and 12. The most significant reduction in amoxicillin and clavulanic acid occurred at ambient temperature (<30 ° C), while the most stable storage conditions for amoxicillin and clavulanic acid levels were at chiller temperature (2-8 ° C). The recommended storage period for bulk products is not more than 4 days.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Amoksisilin, asam klavulanat, waktu, suhu, kadar ---- Amoxicillin, clavulanic acid, time, temperature, concentration |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 02:48 |
| Last Modified: | 02 Oct 2024 02:48 |
| URI: | http://repository.stfi.ac.id/id/eprint/1373 |
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