SRY DEVI SARTIKA, - (2020) HUBUNGAN TERAPI KANKER DENGAN KEJADIAN MIELOSUPRESI PADA PASIEN KANKER PAYUDARA YANG MENDAPATKAN PROTOKOL TC, PEC , AC DI SALAH SATU RUMAH SAKIT SWASTA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Pengobatan kanker payudara dilakukan dengan kemoterapi. Pemberian obat kemoterapi sesuai protokol pengobatan, salah satu dari protokol pengobatan kanker payudara ini diantaranya TC (Docetaxcel,Cyclophosphamid), AC (Doxorubicin,Cyclophosphamid) dan PEC (Paclitaxcel,Epirubicin, Cyclophospha mid) protokol pengobatan ini dilakukan dengan mengkombinasikan obat kemoterapi. Obat - obat kemoterapi ini memiliki efek samping yang serius salah satunya mielosupresi yaitu penurunan kadar hemoglobin, leukosit, dan trombosit. Penelitian ini bertujuan untuk mengetahui efek mielosupresi terbesar dari ketiga protokol pengobatan kanker payudara, serta mengetahui penanganan bila terjadinya mielosupresi. Penelitian ini digunakan dengan metode deskriptif bersifat non- ekperimental yang dilakukan dengan metode pengumpulan data rekam medis pasie kanker payudara secara retrospektif yang kemudian dilanjukan uji t- Tukey. Didapatkan pasien kanker payudara yang mendapatkan protokol AC sebanyak 7 pasien, protokol TC sebanyak 44 pasien dan protokol PEC sebanyak 16 pasien. Terdapat perbedaan bermakna pada kadar hemoglobin (p=0,000) antara protokol AC dengan TC dan terdapat perbedaan bermakna pada kadar leukosit (p=0,000) pada protokol AC dengan TC dan protokol TC dengan PEC. Terdapat perbedaan bermakna pada kadar trombosit (p=0,000) pada protokol pengobatan AC dengan PEC. Persentase penurunan kadar hemoglobin terbesar pada protokol AC sebesar 9,49% dan penurunan leukosit sebesar 18,13%. Persentase penurunan terbesar pada kadar trombosit didapat pada protokol PEC sebesar 13,55%. Sehingga protokol pengobatan yang terbaik di dapat pada protokol TC karena memiliki penurunan hemoglobin paling kecil sebesar 6%, penurunan leukosit sebesar 2,46% dan penurunan trombosit sebesar 0,14%. ---- Treatment of breast cancer is chemotherapy. Giving chemotherapy drugs according to treatment protocols, one of the breast cancer treatment protocols including TC (Docetaxcel, Cyclophosphamid), AC (Doxorubicin,Cyclophospham id) and PEC (Paclitaxcel, Epirubicin, Cyclophosphamid) This treatment protocol is done by combining chemotherapy drugs. These chemotherapy drugs have serious side effects, one of which is myelosuppression, which is a decrease in hemoglobin, leukocyte and platelet levels. This study aims to determine the effect of the largest myelosuppression of the three breast cancer treatment protocols, as well as to determine the treatment when myelosuppression occurs. This study used a descriptive non-experimental method with retrospective method of collecting data on the medical records of breast cancer patients. Then the t-Tukey test was carried out. There were 7 patients with breast cancer who received the AC protocol, 44 patients with TC protocol and 16 patients with PEC protocol. There was a significant difference in hemoglobin levels (p = 0.000) between the AC and TC protocols and there was a significant difference in the levels of leukocytes (p = 0.000) in the AC protocol with TC and the TC protocol with PEC. There was a significant difference in platelet levels (p = 0.000) in the AC treatment protocol with PEC. The largest reduction in hemoglobin concentration in the AC protocol was 9.49% and the decrease in leukocytes was 18.13%. The largest percentage reduction in platelet levels was found in the PEC protocol of 13.55%. So that the best treatment protocol is the TC protocol because it has the smallest decrease in hemoglobin by 6%, a decrease in leukocytes by 2.46% and a decrease in platelets by 0.14%.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Mielosupresi, AC,TC,PEC, Granulocyte Colony Stimulating Factor ---- Myelosuppression, AC,TC,PEC, Granulocyte Colony Stimulating Factor |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 03:07 |
| Last Modified: | 02 Oct 2024 03:07 |
| URI: | http://repository.stfi.ac.id/id/eprint/1365 |
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