MELANI, - (2020) KAJIAN PUSTAKA EFEK FARMAKOLOGI DAN ANALISIS SENYAWA APIGENIN DARI SELEDRI (Apium graveolens L.) UNTUK PENGEMBANGAN OBAT BARU. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Seledri (Apium graveolens L.) merupakan tanaman herba dalam family Apiaceae yang berasal dari Mediterinia dan Timur Tengah. Seledri mengandung apigenin (4′,5,7-trihydroxyflavone, C15H10O5) yang merupakan metabolit sekunder golongan flavonoid flavon. Apigenin telah banyak dimanfaatkan untuk pengobatan berbagai jenis penyakit. Tujuan utama dari tinjauan ini tidak hanya memahami kandungan kimia, dan metodelogi analisis, tetapi juga penggunaan metabolit sekunder apigenin sebagai obat terapeutik untuk dijadikan obat baru. Metode yang digunakan dalam penelitian ini adalah dengan mengkaji dan menganalisis jurnal penelitian yang didapatkan baik jurnal Indonesia maupun luar negeri dengan menggunakan website seperti PubMed, Google Schoolar, NCBI. Dari 70 Jurnal yang didapatkan, kemudian dianalis dan diskrining, sehingga terkumpul 45 jurnal berdasarkan kriteria inklusi. Apigenin direkomendasikan untuk diisolasi dengan menggunakan kromatografi kolom dengan analasis kualitatif menggunakan KLT. Apigenin memiliki 10 aktivitas farmakologi, yang paling banyak diteliti sebagai antikanker, telah dilakukan uji pra-klinik dan uji klink, fase farmakokinetik apigenin diantaranya di absorpsi di usus, didistribusi keseluruh jaringan, metabolism di hati, dieksresikan melalui feses dan urin. Dari data tersebut apigenin dapat digunakan untuk pengembangan obat baru. --- Celery (Apium graveolens L.) is a herbaceous plant in the Apiaceae family that originates from the Mediterranean and Middle East. Celery contains apigenin (4 ′, 5,7-trihydroxyflavone, C15H10O5) which is a secondary metabolite of the flavonoid flavone class. Apigenin has been widely used for the treatment of various types of diseases. The main objective of this review is not only understanding the chemical content, and analytical methodology, but also the use of the secondary metabolite apigenin as a therapeutic drug to be used as a new drug. The method used in this research is to study and analyze research obtained by both Indonesian and foreign journals using websites such as PubMed, Google Schoolar, NCBI. From the 70 journals obtained, they were analyzed and screened, so that 45 journals were collected based on inclusion criteria. Apigenin can be isolated using column chromatography with qualitative analysis using TLC. Apigenin has 10 pharmacological activities, most of which have been studied as an anticancer, preclinical trials and clinking tests have been carried out, apigenin pharmacokinetic phases of which are absorbed in the intestine, distributed throughout tissues, metabolism in the liver, excreted through feces and urine. From these data, apigenin can be used for development of new drugs.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Apigenin, seledri, Apium graveolens L., toksisitas, farmakologi, farmakokinetik, uji klinik, dan obat baru. --- Apigenin, celery, Apium graveolens L., toxicity, pharmacology, pharmacokinetics, clinical trials, and new drugs. |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 03 Oct 2024 06:22 |
| Last Modified: | 03 Oct 2024 06:22 |
| URI: | http://repository.stfi.ac.id/id/eprint/1321 |
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