JESICHA DIAN YENBYEEBE MANOBI, - (2020) KAJIAN PUSTAKA PROSES ISOLASI, ANALISIS DAN AKTIVITAS FARMAKOLOGI SENYAWA SKOPOLETIN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Skopoletin (7-hydroxy-6-methoxy coumarin) merupakan senyawa fenolik kumarin yang banyak ditemukan pada tumbuhan dan termasuk turunan kumarin yang merupakan unggulan pada beberapa jenis tumbuhan. Artikel ini dibuat untuk memberikan informasi mengenai proses isolasi, analisis, dan aktivitas farmakologis. Metode yang digunakan adalah mempelajari dan menganalisis artikel skopoletin dari jurnal nasional dan internasional. Dari sumber data yang ditelaah, didapat rendemen ekstrak skopoletin dalam Morinda citrifolia L yaitu 0,93%, Helichrysum italicum yaitu 1,933mg/100g. Kandungan skopoletin dalam Convolvulus pluricaulis yaitu 0,17%, Artemisia annua yaitu 0,3%, Lasianthus lucidus yaitu 54 mg, dan Morus alba L. (Po-sa) yaitu 0,0009%. Rendemen ekstrak skopoletin terbanyak yaitu 0,93% yang terdapat dalam buah mengkudu (Morinda citrifolia L) dengan menggunakan metode Soxhlet. Kandungan skopoletin tertinggi yaitu 0,3% dalam Artemisia annua dengan menggunakan kolom kromatografi dan direkristralisasi. Identifikasi skopoletin dapat dilakukan dengan menggunakan Kromatografi Lapis Tipis (KLT), Kromatografi Cair Kinerja Tinggi (KCKT), Spektrofotometer Fourier Transform Infra Red (FTIR), Resonansi Magnetik Nuklir, dan Spektrometri Massa. Berdasarkan studi in vitro, skopoletin mempunyai aktivitas farmakologis, antara lain sebagai antihepatotoksisitas, antibakteri, antijamur, antituberkular, dan antioksidan. Aktivitas farmakologi yang sudah dibuktikan secara in vivo yaitu aktivitas antitiroid, antihipertensi, antiproliferatif, antiinflamasi, neurologis, antidopaminergik dan antiadrenergik, antidiabetes, serta antihipperurikemik. Dari berbagai aktivitas farmakologi skopoletin tersebut, dapat berpotensi untuk dikembangkan lebih lanjut. --- Scopoletin (7-hydroxy-6-methoxy coumarin) is a coumarin phenolic compound that is widely found in plants and includes coumarin derivatives which are superior in several types of plants. This article was created to provide information regarding the isolation process, analysis and pharmacological activity. The method used is to study and analyze scopoletin articles from national and international journals. From the data sources studied, the yield of scopoletin extract in Morinda citrifolia L was 0.93%, Helichrysum italicum was 1.933mg / 100g. The scopoletin content in Convolvulus pluricaulis is 0.17%, Artemisia annua is 0.3%, Lasianthus lucidus is 54 mg, and Morus alba L. (Po-sa) is 0.0009%. The highest yield of scopoletin extract was 0.93% found in noni (Morinda citrifolia L) using the Soxhlet method. The highest scopoletin content was 0.3% in Artemisia annua using column chromatography and recrystallization. Scopoletin identification can be done using Thin Layer Chromatography (TLC), High Performance Liquid Chromatography (HPLC), Fourier Transform Infrared Spectrophotometer (FTIR), Nuclear Magnetic Resonance, and Mass Spectrometry. Based on in vitro studies, scopoletin has pharmacological activities, including as an antihepatotoxicity, antibacterial, antifungal, antitubercular, and antioxidant. Pharmacological activities that have been proven in vivo are antithyroid, antihypertensive, antiproliferative, antiinflammatory, neurological, antidopaminergic and antiadrenergic, antidiabetic, and antihyperuricemic activities. From the various pharmacological activities of scopoletin, it has the potential to be further developed.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | skopoletin, isolasi, analisis, aktivitas farmakologi. ----- scopoletin, isolation, analysis, pharmacological activity |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 03 Oct 2024 04:01 |
| Last Modified: | 03 Oct 2024 04:19 |
| URI: | http://repository.stfi.ac.id/id/eprint/1310 |
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