SARAH RIFKA RAHMAWATI, - (2022) PENGUJIAN KELARUTAN OPTIMUM ISOLAT KURKUMIN DALAM PELARUT ETANOL, N-HEKSANA, ETIL ASETAT, DAN ASETON DENGAN MENGGUNAKAN ANALISIS SPEKTROFOTOMETRI VISIBLE DAN GRAVIMETRI. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Kurkumin merupakan senyawa aktif dari kunyit dengan manfaat yang luar biasa. Pemanfaatan kurkumin sebagai bahan aktif obat tradisional maupun modern memiliki permasalahan pada bioavailabilitas serta pengelolaan isolasi. Seiring perkembangan formulasi, data kelarutan penting bagi peneliti untuk dapat memperoleh data dalam pengembangan formulasi obat, analisis, metode isolasi dan farmasetika. Tujuan dari penelitian ini untuk mengetahui kadar kelarutan senyawa isolat kurkumin yang larut dalam pelarut etil asetat, aseton, etanol, dan n-heksana. Sampel dilarutkan dalam 20 mL pelarut, kemudian dishaker selama ± 24 jam dengan kecepatan 400 rpm yang selanjutnya dianalisis menggunakan spektrofotometri visible. Panjang gelombang yang digunakan 422 nm dengan nilai regresi linier y = 0,2207x – 0,0651 dan nilai r sebesar 0,9996. Berdasarkan pengujian secara gravimetri kelarutan dalam pelarut etil asetat sebesar 21,535 mg/mL, pelarut aseton sebesar 11,362 mg/mL, pelarut etanol sebesar 9,755 mg/mL, dan pelarut n-heksana sebesar 1,307 mg/mL. Nilai kelarutan kurkumin berdasarkan analisis spektrofotometri visible dalam pelarut etil asetat sebesar 16,69 mg/mL, pelarut aseton sebesar 7,395 mg/mL, pelarut etanol sebesar 7,856 mg/mL, dan pelarut n-heksana sebesar 0,1015 mg/mL. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa analisis menggunakan metode spektrofotometri visible memperoleh hasil lebih baik dan ketelitian tinggi dibandingkan analisis metode gravimetri. --- Curcumin is the active compound of turmeric with extraordinary benefits. The use of curcumin as an active ingredient in traditional and modern medicine has problems in bioavailability and isolation management. Along with the development of formulations, solubility data is important for researchers to be able to obtain data in drug formulation development, analysis, isolation methods and pharmaceuticals. The purpose of this study was to determine the solubility of curcumin isolate compounds which were soluble in ethyl acetate, acetone, ethanol, and n-hexane solvents. The sample was dissolved in 20 mL of solvent, then shaker for ± 24 hours at a speed of 400 rpm, then d. Analyzed using visible spectrophotometry. in methanol solvent. The wavelength used is 422 nm with a linear regression value of y = 0,2207x – 0,0651 and an r value of 0,9996. Based on the test results based on the solubility value using gravimetric analysis, the solubility in ethyl acetate solvent was 21,535 mg/mL, acetone solvent was 11,362 mg/mL, ethanol solvent was 9,755 mg/mL, and n-hexane solvent was 1,307 mg/mL. The solubility value of curcumin based on visible spectrophotometric analysis in ethyl acetate solvent was 16,69 mg/mL, acetone solvent was 7,395 mg/mL, ethanol solvent was 7,856 mg/mL, and hexane solvent was 0,1015 mg/mL. Based on the results of this study, it can be concluded that the analysis using the visible spectrophotometric method obtained better results and high accuracy than the gravimetric method analysis.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Kurkumin, Uji Kelarutan, Gravimetri, Spektrofotometri Visible --- Curcumin, Solubility Test, Gravimetry, Visible Spectrophotometry |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 14 Sep 2024 14:25 |
| Last Modified: | 19 Sep 2024 04:12 |
| URI: | http://repository.stfi.ac.id/id/eprint/1244 |
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