KARAKTERISASI SIFAT FISIK ISOLAT KURKUMIN DARI TANAMAN KUNYIT(Curcuma domestica Val.)

NURUL HASNA KAMILIYA PUTRI, - (2022) KARAKTERISASI SIFAT FISIK ISOLAT KURKUMIN DARI TANAMAN KUNYIT(Curcuma domestica Val.). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Senyawa kurkumin memiliki banyak manfaat yang sangat baik untuk kesehatan tubuh. Banyaknya manfaat dari senyawa kurkumin membuat senyawa ini mulai dikembangkan menjadi suatu produk sediaan farmasi. Namun permasalahannya yaitu belum ada data karakteristik senyawa kurkumin yang dapat digunakan sebagai data preformulasi sehingga produk farmasi berbasis isolat kurkumin belum bisa dikembangkan. Tujuan dari penelitian ini yaitu untuk mengetahui dan mengidentifikasi karakteristik fisik dari isolat kurkumin sehingga bisa dimanfaatkan sebagai data preformulasi untuk pengembangan produk farmasi berbasis isolat kurkumin. Penelitian karakteristik fisik dari isolat kurkumin yaitu meliputi karakterisasi titik leleh menggunakan Differential Scanning Calorimetry (DSC), karakterisasi kristalografi menggunakan Powder X-ray Diffractometry (PXRD), karakterisasi morfologi permukaan menggunakan Scanning Electron Microscopy (SEM), pengukuran nilai zeta potensial menggunakan Zeta Potential Analyzer (ZPA), penentuan tap density, penentuan true density dan uji kelarutan terhadap pelarut propilenglikol, PEG 400, gliserin dan sorbitol. Hasil penelitian menunjukkan bahwa isolat kurkumin memiliki nilai indeks rata-rata kompresibilitas sebesar 16,463%; true density 1,116 g/mL; titik leleh 169,63; morfologi partikel berbentuk balok panjang, bersifat kristal, nilai zeta potensial - 59,8 mV dan isolat kurkumin mudah larut dalam PEG 400. Berdasarkan hasil pengamatan dapat disimpulkan bahwa isolat kurkumin bersifat Kristal dengan bentuk morfologi balok panjang, bersifat mampat, memiliki laju alir yang cukup baik, stabil pada pemanasan dan tidak mudah teraglomerasi. --- Curcumin compounds have many benefits that are very good for the health of the body. The many benefits of curcumin compounds make this compound began to be developed into a pharmaceutical product. However, the problem is that there is no data on the characteristics of curcumin compounds that can be used as preformulation data so that pharmaceutical products based on curcumin isolates cannot be developed. The purpose of this study was to determine and identify the physical characteristics of curcumin isolates so that they could be used as preformulation data for the development of pharmaceutical products based on curcumin isolates. Research on the physical characteristics of curcumin isolates included melting point characterization with Differential Scanning Calorimetry (DSC), crystallographic characterization with Powder X-ray Diffractometry (PXRD), surface morphology characterization with Scanning Electron Microscopy (SEM), measuring zeta potential value with a Zeta Potential Analyzer (ZPA), tap density, true density and solubility test of propylene glycol, PEG 400, glycerin and sorbitol solvents. The results of the study showed that curcumin isolates had an average compressibility index of 16.463%; true density 1.116 g/mL; melting point 169.63; particle morphology in the form of long beams,was crystal; zeta potential value -59, mV and curcumin isolate was easily soluble in PEG 400. Based on the result of the study, it can be concluded that curcumin isolates are amorphous with long beam morphology, are incompressible, have a fairly good flow rate, are stable on heating and are not easily agglomerated.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Karakterisasi, Karakteristik, Kurkumin, Isolat --- Characterization, Characteristics, Curcumin, Isolate
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Sep 2024 13:41
Last Modified:	14 Sep 2024 13:41
URI:	http://repository.stfi.ac.id/id/eprint/1208

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