DENIA ALVIRA TEZANINGRUM, - (2021) PENENTUAN KADAR MANGOSTIN PLASMATIK IN VITRO DALAM FORMULA TABLET SUPLEMEN JET-20 DENGAN MENGGUNAKAN METODE KROMATOGRAFI CAIR KINERJA TINGGI (KCKT). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Suplemen JET-20 adalah tablet oral yang formulanya dirancang para peneliti di STFI, memiliki kandungan senyawa aktif mangostin, piperin, kurkuminoid, metil sinamat, serta vitamin C. Suplemen ini telah terbukti berkhasiat untuk meningkatkan ketahanan tubuh terutama pada pasien yang terserang berbagai macam penyakit, dan juga infeksi virusis seperti pada kasus HIV dan COVID-19. Penelitian ini bertujuan untuk melakukan analisis kuantitatif kandungan senyawa aktif mangostin dalam formula tablet suplemen JET-20 yang berada dalam larutan plasmatik secara in-vitro dengan menggunakan metode Kromatografi Cair Kinerja Tinggi (KCKT). Analisis yang dilakukan belum menunjukkan hasil yang diharapkan. Proses ekstraksi dari larutan plasma menjadi kendala utama dalam memperoleh kembali bentuk mangostin murni untuk dianalisis dengan KCKT. Waktu retensi sulit ditentukan karena masih banyaknya pengotor endogen plasmatik yang ikut terbawa pada saat ekstraksi. --- The JET-20 supplement is an oral tablet whose formula was designed by researchers at STFI, containing the active compounds mangostin, piperine, curcuminoids, methyl cinnamate, and vitamin C. This supplement has been shown to be efficacious for increasing body resistance, especially in patients suffering from various diseases, as well as viral infections such as in the case of HIV and COVID-19. This study aimed to conduct a quantitative analysis of the active compound content of mangostin in the JET-20 supplement tablet formula in in vitro plasmatic solution using the High Performance Liquid Chromatography (HPLC) method. The analysis has not shown the expected results. The extraction process from plasma solution became the main obstacle in recovering pure mangostin form for analysis by HPLC. Retention time is difficult to determine because there are still many endogenous plasmatic impurities that are carried away during extraction.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | Suplemen JET-20, ekstraksi plasmatik, KCKT --- JET-20 supplement, plasmatic extraction, HPLC |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 07 Sep 2024 02:04 |
| Last Modified: | 07 Sep 2024 02:04 |
| URI: | http://repository.stfi.ac.id/id/eprint/1143 |
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