PENGARUH PEMBENTUKAN KOKRISTAL FLUCONAZOLE- ASAM TARTRAT MENGGUNAKAN METODE SOLVENT DROP GRINDING TERHADAP KELARUTAN

NURHALIMAH, - (2021) PENGARUH PEMBENTUKAN KOKRISTAL FLUCONAZOLE- ASAM TARTRAT MENGGUNAKAN METODE SOLVENT DROP GRINDING TERHADAP KELARUTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Fluconazole merupakan obat antijamur yang termasuk dalam Biopharmaceutical Classification System (BCS) kelas II yang memiliki kelarutan yang rendah dan permeabilitas tinggi. Tujuan dari penelitian ini yaitu meningkatkan kelarutan fluconazole dalam air melalui pembentukan kokristal menggunakan asam tartrat sebagai koformer. Fluconazole dan asam tartrat dibuat dengan perbandingan molar 1:1, 1:2, dan 2:1. Pembuatan kokristal dilakukan menggunakan metode solvent drop grinding. Hasil kokristal fluconazole-asam tartrat karakterisasi dengan difraksi sinar-X dan spektrofotometer FTIR. Berdasarkan hasil uji difraksi sinar- X pada kokristal memiliki puncak difraksi baru dan hasil spektrofotometer FTIR adanya pergeseran bilangan gelombang yang menunjukkan terbentuk ikatan hidrogen. Hasil uji kelarutan menunjukkan bahwa kokristal perbandingan 1:1 mengalami peningkatan 1,51 kali, 1:2 mengalami peningkatan paling tinggi yaitu 1,65 kali dan 2:1 meningkat 1,43 kali. --- Fluconazole is an antifungal drug that belongs to the Biopharmaceutical Classification System (BCS) class II which has low solubility and high permeability. The purpose of this study was to increase the solubility of fluconazole in water through the formation of cocrystals using tartaric acid as a coformer. Fluconazole and tartaric acid were prepared in a molar ratio of 1:1, 1:2, and 2:1. Cocrystals were made using the solvent drop grinding method. The fluconazole- tartaric acid cocrystal results were characterized by X-ray diffraction and FTIR spectrophotometer. Based on the results of the X-ray diffraction test, the cocrystal has a new diffraction peak and the results of the FTIR spectrophotometer have a shift in wave number indicating hydrogen bonds are formed. The results of the solubility test showed that the ocrystal ratio of 1:1 increased 1.51 times, 1:2 experienced the highest increase of 1.65 times and 2:1 increased by 1.43 times.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: luconazole, asam tartrat, kokristal, solvent drop grinding, kelarutan --- fluconazole, tartaric acid, cocrystal, solvent drop grinding, solubility.
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
Divisions: Program Studi S1 Farmasi
Depositing User: pustakawan - -
Date Deposited: 07 Sep 2024 02:58
Last Modified: 07 Sep 2024 02:58
URI: http://repository.stfi.ac.id/id/eprint/1116

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