NOVIANTI FAUZIAH, - (2024) STUDI INKOMPATIBILITAS ANTARA ISOLAT ALFAMANGOSTIN DENGAN BASIS SEDIAAN TABLET EFFERVESCENT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Alfa-Mangostin, senyawa aktif utama dalam kulit manggis, yang telah dikenal memiliki aktivitas antikanker dan antioksidan. Potensinya untuk dikembangkan menjadi sediaan tablet effervescent terhambat karena belum adanya penelitian terkait inkompatibilitas. Oleh karena itu, penelitian ini bertujuan untuk menganalisis potensi inkompatibilitas antara isolat alfa-mangostin dan eksipien tablet effervescent, yaitu asam sitrat, asam tartat, dan natrium bikarbonat. Metode penelitian meliputi preparasi sampel, analisis organoleptik, morfologi, homogenitas, kristalinitas, sifat termal, dan Loss on Dry (LoD). Pencampuran dilakukan dengan perbandingan alfa-mangostin:eksipien 1:1 pada kecepatan 60 rpm selama 30 menit. Hasil penelitian menunjukkan alfa-mangostin dengan asam sitrat terdapat aglomerasi dan memiliki homogenitas yang rendah, sedangkan alfamangostin dengan asam tartat dan natrium bikarbonat tidak mengalami aglomerasi dan memiliki homogenitas yang baik. Difraktogram dan termogram campuran alfamangostin dengan asam sitrat, asam tartat dan natrium bikarbonat menunjukkan bahwa sampel mempertahankan struktur dan bentuknya masing-masing. Hasil LoD dari masing-masing sampel campuran memenuhi persyaratan. Berdasarkan penelitian ini, dapat disimpulkan bahwa alfa-mangostin dengan asam sitrat, asam tartat dan natrium bikarbonat diduga memiliki potensi yang rendah untuk mengalami inkompatibilitas. ---- Alpha-mangostin, the primary active compound in mangosteen peel, is renowned for its anticancer and antioxidant activities. However, lacking incompatibility research hinders its potential development into effervescent tablets. This study analyzes the potential incompatibility between alpha-mangostin and common effervescent tablet excipients: citric acid, tartaric acid, and sodium bicarbonate. The research methodology encompassed sample preparation, organoleptic analysis, morphology examination, homogenization assessment, crystallinity evaluation, thermal property analysis, and Loss on Drying (LoD) determination. Mixing was conducted with a 1:1 ratio of alpha-mangostin to excipients at 60 rpm for 30 minutes. Results revealed that alpha-mangostin mixed with citric acid exhibited agglomeration and poor homogenization. In contrast, alpha-mangostin mixtures with tartaric acid and sodium bicarbonate showed no agglomeration and good homogenization. X-ray diffraction and thermal analyses of all mixtures indicated that the components retained their respective structures and forms. LoD results for all mixtures met the required standards. It can be concluded that alphamangostin exhibits a low potential for incompatibility with citric acid, tartaric acid, and sodium bicarbonate.
Item Type: | Thesis (Skripsi) |
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Uncontrolled Keywords: | Inkompatibilitas, Alfa-mangostin, Asam sitrat, Asam Tartat, Natrium Bikarbonat ----- Incompatibility, Alpha-Mangostin, Citric Acid, Tartaric Acid, Sodium Bicarbonate |
Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
Divisions: | Program Studi S1 Farmasi |
Depositing User: | pustakawan - - |
Date Deposited: | 28 Aug 2024 04:05 |
Last Modified: | 28 Aug 2024 04:05 |
URI: | http://repository.stfi.ac.id/id/eprint/1092 |
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