IJAH HOTIJAH, - (2024) KARAKTERISASI DISPERSI PADAT AMORF ISOLAT α-MANGOSTIN (Garcinia mangostana L.) MENGGUNAKAN POLIMER POLYVINYL PYROLIDONE (PVP) K-30 DENGAN METODE SOLVENT EVAPORATION. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
α-mangostin bersifat hidrofobik dengan kelarutan rendah, tapi permeabilitas tinggi sehingga tergolong kelas II Sistem Klasifikasi Biofarmasi (BCS). α-mangostin dalam bentuk kristal menyebabkan bioavailabilitas rendah dibandingkan amorf. Namun, amorf tidak stabil dan mudah terekristalisasi, untuk mengatasi hal tersebut maka dilakukan mendispersikan amorf ke dalam PVP K-30 untuk membentuk dispersi padat amorf (SDA). Tujuan penelitian ini untuk membentuk SDA α-mangostin menggunakan PVP K-30 dengan metode solvent evaporation. SDA α-mangostin dibuat menggunakan isolat α-mangostin dan PVP K-30 dengan perbandingan 1:1; 1:3; 1:5; 1:7; dan 1:9 b/b dalam pelarut etanol pada suhu ± 40°C. SDA dikarakterisasi menggunakan Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), dan Fourier Transform Infrared Spectroscopy (FTIR). Hasil menunjukkan seluruh SDA mengalami penurunan kristalinitas, termogram SDA menunjukkan pergeseran transisi glass ke suhu yang lebih tinggi, dan spektrum FTIR SDA mengalami pembentukan hidrogen antara α-mangostin dan PVP K-30 dimana bilangan gelombang gugus fungsi O-H bergeser ke bilangan gelombang rendah dan C=O ke lebih tinggi. Dari berbagai perbandingan, SDA 1:3 menunjukkan kritalinitas yang paling rendah. Berdasarkan hasil tersebut, disimpulkan bahwa α-mangostin dan PVP K-30 berhasil membentuk SDA menggunakan metode solvent evaporation. SDA terbaik yang dibentuk adalah SDA dengan perbandingan α-mangostin dan PVP K-30 1:3. ----- α-mangostin is hydrophobic with low solubility, but high permeability so it is classified as class II of the Biopharmaceutical Classification System (BCS). α-mangostin in crystal form causes lower bioavailability compared to amorphous. However, amorphous is unstable and easily recrystallizes, to overcome this, the amorphous is dispersed into PVP K-30 to form an amorphous solid dispersion (ASD). The aim of this research is to form ASD α-mangostin using PVP K-30 using the solvent evaporation method. α-mangostin ASD was made using α-mangostin isolate and PVP K-30 in a ratio of 1:1; 1:3; 1:5; 1:7; and 1:9 w/w in ethanol solvent at a temperature of ± 40°C. ASD was characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared Spectroscopy (FTIR). The results show that all ASD experienced a decrease in crystallinity, the ASD thermogram showed a shift in the glass transition to a higher temperature, and the FTIR spectrum of ASD experienced hydrogen formation between α-mangostin and PVP K-30 where the wave number of the O-H functional group shifted to a low wave number and C=O to higher. From various comparisons, ASD 1:3 shows the lowest crystallinity. Based on these results, it was concluded that α-mangostin and PVP K-30 succeeded in forming ASD using the solvent evaporation method. The best ASD that was formed was ASD with a ratio of α-mangostin and PVP K-30 of 1:3.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | α-Mangostin, PVP, Dispersi Padat Amorf. ------ α-Mangostin, PVP, Amorphous Solid Dispersion. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 26 Aug 2024 07:06 |
| Last Modified: | 26 Aug 2024 07:06 |
| URI: | http://repository.stfi.ac.id/id/eprint/1063 |
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