STUDI KOMPATIBILITAS ISOLAT KURKUMIN TERHADAP EKSIPIEN LUBRIKAN DAN GLIDAN PADA SEDIAAN SOLID

CATHERINE AVERINA, - (2024) STUDI KOMPATIBILITAS ISOLAT KURKUMIN TERHADAP EKSIPIEN LUBRIKAN DAN GLIDAN PADA SEDIAAN SOLID. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Inkompatibilitas merupakan kejadian di mana obat tidak tercampur secara fisika maupun kimia yang berpotensi menyebabkan perubahan secara farmakologis atau perubahan lainnya. Tujuan penelitian ini untuk memperoleh data potensi inkompatibilitas antara isolat kurkumin dan eksipien yang berfungsi sebagai lubrikan dan glidan dalam formulasi sediaan solid, diantaranya adalah talk, magnesium stearat, dan silika. Campuran sampel dianalisis secara fisikokimia dengan menggunakan metode Differential Scanning Calorimetry (DSC) untuk menganalisis sifat termal sampel dan X-Ray Diffraction (XRD) untuk menganalisis struktur kristal sampel. Berdasarkan hasil penelitian diperoleh kurkumin pada analisis sifat termal dengan Differential Scanning Calorimetry (DSC) dan analisis kristalinitas dengan X-Ray Diffraction (XRD) tidak menunjukkan adanya perubahan secara signifikan yang berpotensi terhadap inkompatibilitas terhadap eksipien talk, magnesium stearat, dan silika. ---- Incompatibility was an event where the drug did not mix physically or chemically, potentially causing pharmacological changes or other alterations. The purpose of this research was to obtain data on the potential incompatibility between curcumin isolate and excipients that functioned as lubricants and glidants in solid dosage formulations, including talc, magnesium stearate, and silica. The sample mixtures were analyzed physicochemically using the Differential Scanning Calorimetry (DSC) method to analyze the thermal properties of the samples and X-Ray Diffraction (XRD) to analyze the crystal structure of the samples. Based on the research results, curcumin, in the analysis of thermal properties using Differential Scanning Calorimetry (DSC) and crystallinity analysis using X-Ray Diffraction (XRD), did not show any significant changes that could indicate potential incompatibility with the excipients talc, magnesium stearate, and silica.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	inkompatibilitas, kristalinitas, titik leleh, kurkumin, eksipien. ---- incompatibility, crystallinity, melting point, curcumin, excipients
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	26 Aug 2024 06:30
Last Modified:	26 Aug 2024 06:30
URI:	http://repository.stfi.ac.id/id/eprint/1059

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