RAFI ABDILLAH HAFID, - (2023) PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN CINCAU HITAM (Mesona palustris BL) TERHADAP KADAR MALONDIALDEHID (MDA) TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L) DISLIPIDEMIA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Cincau hitam (Mesona palustris BL) merupakan tanaman kaya antioksidan yang memiliki khasiat dan sudah terbukti secara ilmiah memiliki aktivitas diabetes dan, dislipidemia. Dislipidemia adalah kondisi medis di mana terjadi ketidakseimbangan dalam kadar lipid yang mampu memicu terjadinya produksi radikal bebas yang berlebih. Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh pemberian ekstrak etanol cincau hitam pada hewan coba tikus dislipidemia terhadap penurunan kadar malondialdehid. Ekstraksi daun cincau hitam menggunakan etanol 96%. Tikus jantan sebanyak 24 ekor dibagai menjadi 6 kelompok yaitu kelompok negatif, positif, pembanding simvastatin dan ekstrak etanol daun cincau hitam dosis 200, 400, 600 mg/Kg BB, semua kelompok hewan uji diinduksi dengan pakan kaya lemak dan propylthiouracil (PTU) 12,5 mg/kg BB, kolesterol murni 200 mg/Kg BB, dan asam kolat 75 mg/Kg BB selama 3 minggu. Pengukuran MDA pada hati tikus menggunakan spektrofotometer UV-Vis. Data yang diperoleh diuji dengan anova satu arah, dan dilanjutkan dengan uji LSD. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol daun cincau hitam mampu menurunkan kadar malondialdehid, penurunan kadar yang paling baik dan signifikan ditunjukkan pada dosis ekstrak etanol daun cincau hitam dosis 600 mg/kg BB dengan hasil rata-rata yang didapatkan sebesar 0,131 nmol/Ml dan hasil pada kelompok pembanding simvastatin mendapatkan sebesar 0,148. --- Black grass jelly (Mesona palustris BL) is an antioxidant-rich plant with scientifically proven activity in diabetes and dyslipidemia. Dyslipidemia is a medical condition in which there is an imbalance in lipid levels that can trigger excessive free radical production. The purpose of this study was to determine how the effect of giving black grass jelly ethanol extract to dyslipidemia rats on reducing malondialdehyde levels. Extraction of black grass jelly leaves using 96% ethanol. Male rats as many as 24 heads were divided into 6 groups, namely negative, positive, simvastatin comparison and ethanol extract of black grass jelly leaves in doses of 200, 400, 600 mg / kg BW, all groups of test animals were induced with fat-rich feed and propylthiouracil (PTU) 12.5 mg / kg BW, pure cholesterol 200 mg/ kg BW, and cholic acid 75 mg / kg BW for 3 weeks. Measurement of MDA in rat liver using UV-Vis spectrophotometer. The data obtained were tested with one-way ANOVA, and continued with LSD test. The results showed that the administration of ethanol extract of black grass jelly leaves was able to reduce malondialdehyde levels, the best and significant decrease in levels was shown in the dose of ethanol extract of black grass jelly leaves at a dose of 600 mg / kg BW with the average result obtained of 0.131 nmol / ml and the results in the simvastatin comparison group obtained 0.148.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Antioksidan, Cincau Hitam, Dosis, Kadar MDA Malondialdehid Black grass jelly antioxidants, Dosage of Malondialdehyde MDA Levels |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 15 Jun 2024 04:33 |
| Last Modified: | 25 Jun 2024 02:51 |
| URI: | http://repository.stfi.ac.id/id/eprint/230 |
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