Biota Laut Sebagai Antivirus COVID-19 : Review

Riasari, Hesti (2022) Biota Laut Sebagai Antivirus COVID-19 : Review. Biota Laut Sebagai Antivirus COVID-19 : Review, 2 (1). pp. 49-54. ISSN 2964-6154

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Abstract

The outbreak of Corona Virus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has hit the world. Until now, only vaccines have been found as an effort to prevent COVID-19 but no therapeutic drugs have been found, so drug discovery, especially from drugs with specific structures, will help the urgency. The discovery of construction drugs using plants isolate computational modeling has been widely carried out, while in marine biota are still few. Whereas the potential of marine biota as structural medicine is very large because its diversity is very wide and until now it is still under-explored. This systematic review was carried out to identify compounds from marine biota that may be antiviral for COVID-19 based on the search for compounds from plants that have the most potential as antiviral-COVID-19 by in silico molecular docking. This review begins with the search for the 10 most recent topics that raise the topic of potential compounds of natural ingredients in plants as COVID-19 antivirals in silico, then a library search of potential compounds on natural plant materials in marine biota on the Google Schoolar database. The results of docking Sars-COV2 main protease (Mpro 6LU7) showed kaemppherol, gamma mangostin, nigelidin compounds with a dcore of -7.8, with a difference in the docking score of the control compound, namely Lopinavir (-0.4). From this review, it was found that flavonols are flavonoid compounds with the most potential chemical as anti Main Protease (MPro) of SARS-CoV-2, and can be found in 10 marine biota which are: Fire Mangroves, White Snapper, Sea Lettuce, Golden Sea Cucumber, Butoh Rivet Sea Cucumber, Red Algae, Local Seaweed and other Seaweeds.

Item Type:	Article
Subjects:	R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica
Divisions:	> A General Works > AS Academies and learned societies (General) A General Works > AS Academies and learned societies (General)
Depositing User:	pustakawan - -
Date Deposited:	29 Feb 2024 08:46
Last Modified:	25 Apr 2024 06:30
URI:	http://repository.stfi.ac.id/id/eprint/149

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