Acute toxicity test of tablets containing α-mangosteen, piperine, curcumin, methyl cinnamate and vitamin C in female wistar rats

NIA KURNIA SARI, - and SRIWIDODO, - and NOVI IRWAN FAUZI, - and AJENG DIANTINI, - and DIKI PRAYUGO WIBOWO, - (2024) Acute toxicity test of tablets containing α-mangosteen, piperine, curcumin, methyl cinnamate and vitamin C in female wistar rats. The Pharmacy Education, 24 (2). pp. 158-162. ISSN 1560-2214

Text 9. Penelitian -Q3_Acutetoxicitytestoftabletscontainingα-mangosteenpiperinecurcuminmethylcinnamateandvitaminCinfemalewistarrats.pdf Download (752kB)

Abstract

Background: Traditional medicine has long been used and contributed to health services. Supplement tablets containing isolated -mangosteen, piperine, curcumin, methyl cinnamate, and vitamin C are potential antivirals. Objective: This study determined the LD50 of these supplement tablets as well as their influence on the liver, stomach, kidneys, spleen, and lungs after the acute oral administration of 5000 mg/kg to female Wistar rats, according to the OECD 425 Up and Down Procedure. Method: The test animals were observed for signs of toxicity for 14 days, the first 48 hours, with observation especially in the first 4 hours every 30 minutes. Results: They showed no signs of toxicity and non-irritating death and had an LD50 toxicity value >5000 mg/kg body weight. Therefore, the tablets were deemed practically non-toxic. Histopathology revealed no changes in the liver, spleen, and lungs, however desquamation and ulceration of the stomach and glomerular degeneration and atrophy in the kidney were light and reversible. Conclusion: The tablets containing isolated α-mangosteen, piperine, curcumin, methyl cinnamate and vitamin C were practically non-toxic.

Item Type:	Article
Uncontrolled Keywords:	Curcumin, Isolate, Mangosteen, Methyl cinnamate Piperin
Subjects:	Q Science > Q Science (General)
Divisions:	Lembaga Penelitian dan Pengabdian Masyarakat > Publikasi Penelitian
Depositing User:	Diki Prayugo Wibowo
Date Deposited:	17 Aug 2024 19:27
Last Modified:	17 Aug 2024 19:27
URI:	http://repository.stfi.ac.id/id/eprint/883

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