Development Of Molecularly Imprinted Polymer Microspheres Made By Surface Imprinting For Purification Of Andrographolide

WIWIN WININGSIH, - and SOPHI DAMAYANTI, - and SLAMET IBRAHIM, - (2022) Development Of Molecularly Imprinted Polymer Microspheres Made By Surface Imprinting For Purification Of Andrographolide. RASĀYAN Journal of Chemistry, 15 (2). 1296-1305|. ISSN 0974-1496

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Abstract

Molecularly imprinted polymer microspheres (MIPs) are used for the separation and purification process of synthetic and natural products due to their high selectivity for certain molecules. In this development, we aimed to synthesize, characterize, and apply MIPs for andrographolide purification. The synthesis was carried out by surface imprinting technique with silica microspheres as a solid support, andrographolide as a template molecule, 3- aminopropyltriethoxylane (APTES) as a functional monomer, tetraethyl orthosilicate (TEOS) as a crosslinker, and methanol as porogen solvent. Furthermore, synthesized MIPs were characterized by Fourier Transform Infra-Red (FTIR) and Scanning Electron Microscope. Based on the results, the adsorption capacity of the polymer was 0.5679 mg/g, while the imprinting factor was 3.9305 The MIPs showed good selectivity against quercetin with a selectivity factor of 3.4305, while the percentage of purity for crude andrographolide (AP) increased from 55.37 % ± 0.69 to 92.92 % ± 0.48 after being purified by the MIPs. The isolates characterization results showed similarity with the standard andrographolide.

Item Type: Article
Uncontrolled Keywords: Molecularly Imprinted Polymer Microspheres, Surface Imprinting, Andrographolide, 3- Aminopropyltriethoxylane (APTES), Tetraethyl Orthosilicate (TEOS), Silica Microspheres.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Lembaga Penelitian dan Pengabdian Masyarakat > Publikasi Penelitian
Depositing User: - Wiwin Winingsih -
Date Deposited: 18 Aug 2024 14:22
Last Modified: 18 Aug 2024 14:22
URI: http://repository.stfi.ac.id/id/eprint/867

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