LIMBONG NOVITA, - (2021) PENGARUH PEMBENTUKAN KOKRISTAL IBUPROFEN-NIKOTINAMID DENGAN MENGGUNAKAN METODE SOLVENT DROP GRINDING TERHADAP KELARUTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Ibuprofen merupakan obat Non Steroid Anti Inflammation Drug (NSAID) yang digunakan secara luas sebagai antiinflamasi. Berdasarkan Biopharmaceutical Classification System (BCS) ibuprofen termasuk BCS kelas II dengan sifat permeabilitas tinggi dan kelarutan yang rendah, sehingga menyebabkan bioavailibilitasnya menjadi rendah. Penelitian ini bertujuan untuk meningkatkan kelarutan ibuprofen melalui pembentukan kokristal antara ibuprofen dan nikotinamid perbandingan 1:1 dengan metode Solvent Drop Grinding menggunakan pelarut etanol 96%. Hasil kokristalisasi dikarakterisasi dengan spektrofotometer Fourier Transform Infrared (FTIR), Powder X-Ray Diffraction (PXRD), dan uji kelarutan di dalam air. Hasil penelitian menunjukkan adanya pergeseran bilangan gelombang, pergeseran ini mengindikasikan keberadaan formasi ikatan hidrogen antara ibuprofen dan nikotinamid yang berperan dalam proses kokristalisasi hasil spektrofotometer Fourier Transform Infrared (FTIR), adanya puncak dan intensitas yang berbeda pada difraktogram hasil Powder X-Ray Diffraction (PXRD), pada uji kelarutan terjadi peningkatan kelarutan kokristal ibuprofen dan nikotinamid dengan perbandingan 1:1 lebih tinggi 2,48 kali dibandingkan kelarutan ibuprofen murni. Kesimpulan berdasarkan penelitian dan hasil analisis data adalah bahwa dengan metode Solvent Drop Grinding dapat membentuk kokristal Ibuprofen-nikotinamid. Pembentukan kokristal pada perbandingan ibuprofen-nikotinamid 1:1 mengalami peningkatan kelarutan dan diperoleh hasil peningkatan kelarutan yaitu 2,48 kali dibandingkan dengan ibuprofen karena terbentuk ikatan hidrogen dan kristanilitas yang paling rendah. ---- Ibuprofen is a Non Steroid Anti Inflammation Drug (NSAID) which is widely used as an anti inflammation. Based on the Biopharmaceutical Classification System (BCS), ibuprofen belongs to BCS class II with high permeability and low solubility, which causes low bioavailability. This study aims to increase the solubility of ibuprofen through the formation of cocrystals between ibuprofen and nicotinamide in a 1:1 ratio with the Solvent Drop Grinding method using 96% ethanol as a solvent with a ratio of 1:1. The cocrystallization results were characterized by Fourier Transform Infrared (FTIR) spectrophotometer, Powder X-Ray Diffraction (PXRD), and water solubility test. The results showed a shift in wave number, this shift indicated the presence of hydrogen bond formation between ibuprofen and nicotinamide which played a role in the cocrystallization process of the Fourier Transform Infrared (FTIR) spectrophotometer, the presence of different peaks and intensities in the diffractogram of Powder X-Ray Diffraction (PXRD) results. In the solubility test, there was an increase in the solubility of cocrystals of ibuprofen and nicotinamide with a ratio of 1:1 which was 2.48 times higher than the solubility of pure ibuprofen. The conclusion based on the research and the results of data analysis is that the Solvent Drop Grinding method can form Ibuprofen-nicotinamide cocrystals. The formation of cocrystals at the ratio of ibuprofen-nicotinamide 1:1 experienced an increase in solubility and the results obtained an increase in solubility which was 2.48 times compared to ibuprofen because hydrogen bonds were formed and the lowest crystallinity.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | kokristal, ibuprofen, nikotinamid, karakteristik fisika-kimia. ---- cocrystal, ibuprofen, nicotinamide, physicochemical property. |
| Subjects: | Q Science > QD Chemistry R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 16 Aug 2024 04:04 |
| Last Modified: | 16 Aug 2024 04:04 |
| URI: | http://repository.stfi.ac.id/id/eprint/840 |
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