FITRIA NURLITA, - (2021) PENANDAAN PIRIMETAMIN DENGAN RADIOISOTOP IODIUM-131 SEBAGAI RADIOFARMAKA UNTUK TERAPI TOKSOPLASMA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Toksoplasmosis merupakan penyakit yang memiliki tingkat prevalensi tinggi di dunia. Berbagai teknik diagnosis maupun tindakan terapi telah banyak diupayakan dan dikembangkan, termasuk di bidang kedokteran nuklir. Para peneliti berusaha untuk menemukan solusi dalam penanggulangan penyakit toksoplasmosis melalui teknik diagnosis maupun terapi, salah satunya melalui penggunaan radiofarmaka Pirimetamin bertanda iodium-131. Penelitian ini bertujuan untuk menetapkan kondisi optimal proses penandaan senyawa hirimetamin dengan radioisotop iodium-131 dengan metode kloramin-T agar diperoleh senyawa sen bertanda Pirimetamin yang memenuhi persyaratan radiofarmaka. Efisiensi penandaan serta kemurnian radiokimia senyawa ditentukan dengan metode elektroforesis dan kromatografi lapis tipis menggunakan plat TLC-SG sebagai fase diam dan metanol sebagai fase gerak. Kondisi penandaan dengan menggunakan 1,2 mg/300 µL pirimetamin, 100 µCi Na¹¹¹1, 0,3 mg/60 µL kloramin-T, 0,3 mg/60 µL natrium metabisulfit, waktu inkubasi 5 menit pada suhu kamar, memberikan rendemen 98,69%. ----- Toxoplasmosis is a disease that has a high prevalence rate in the world. Various diagnostic techniques and therapeutic measures have been widely pursued and developed, including in the field of nuclear medicine. Researchers are trying to find solutions in the prevention of toxoplasmosis through diagnostic and therapeutic techniques, one of which is the use of the radiopharmaceutical Pyrimethamine labelling with iodine-131. This study aims to determine the optimal conditions for the marking process of pyrimethamine compounds with the radioisotope iodine-131 with the chloramine-T method in order to obtain compounds marked 111-Pyrimethamine that meet radiopharmaceutical requirements. The labelling efficiency and radiochemical purity of the compounds were determined by electrophoresis and thin layer chromatography using TLC-SG plate as the stationary phase and methanol as the mobile phase. The labelling conditions were 1.2 mg/300 µL pyrimethamine, 100 µCi Na1311, 0.3 mg/60 µL chloramine-T, 0.3 mg/60 µL sodium metabisulfite, incubation time of 5 minutes at room temperature, giving a yield of 98,69%.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | Toksoplasmosis, pirimetamin, iodium-131, optimasi, penandaan. ----- Toxoplasmosis, pyrimethamine, jodium-131, optimization, labelling. |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 16 Aug 2024 01:42 |
| Last Modified: | 16 Aug 2024 01:42 |
| URI: | http://repository.stfi.ac.id/id/eprint/828 |
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