PENINGKATAN KELARUTAN ETIL p-METOKSISINAMAT YANG TERMUAT DALAM MESOPORI SILIKA NANOPARTIKEL

AULIA LATHIFAH, - (2021) PENINGKATAN KELARUTAN ETIL p-METOKSISINAMAT YANG TERMUAT DALAM MESOPORI SILIKA NANOPARTIKEL. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Kelarutan yang rendah dari etil p-metoksisinamat (EPMS) menghambat absdysi EPMS dari saluran gastrointestinal dan memperlambat efek farmakologinya sebagai antiinflamasi. Mesopori silika nanopartikel (MSN) merupakan pembawa yang berpotensi meningkatkan kelarutan zat aktif sukar larut air seperti EPMS. Penelitian ini bertujuan untuk memuat EPMS dalam MSN (EPMS-MSN) dalam rangka meningkatkan kelarutan EPMS dalam air. MSN dibuat dengan prekursor berupa natrium silika dan template berupa tween 80 dan span 80. Sebanyak 500 mg MSN didispersikan ke dalam 2% b/v larutan EPMS, diaduk dengan kecepatan 100 rpm selama 24 jam. EPMS-MSN yang terbentuk kemudian dianalisis Loading Capacity (LC) dan Loading Efficiency (LE), dikarakterisasi ukuran partikel, luas permukaan, diameter dan volume pori, morfologi dalam, gugus fungsi, dan kristalinitas, serta uji kelarutannya. Hasil penelitian menunjukkan MSN berupa serbuk putih dengan bentuk tidak beraturan, ukuran partikel 87,1305 nm, luas permukaan 68,86 m²/g, diameter pori 20,45 nm, volume pori 0,352 cm³/g, dan kristalinitas yang rendah. EPMS-MSN berupa serbuk putih yang memiliki pola difraktogram dan spektrum IR berkesesuaian dengan MSN, dengan nilai LC 10,6% dan LE 18,18%. Uji kelarutan menunjukkan kelarutan EPMS-MSN dalam air mengalami peningkatan sebesar 1,7 kali dibandingkan EPMS. Dengan demikian, dapat disimpulkan bahwa pemuatan EPMS dalam MSN memiliki potensi untuk dapat meningkatkan kelarutan EPMS dalam air. ---- The low solubility of ethyl p-methoxycinnamate (EPMC) inhibits the absorption of EPMC from the gastrointestinal tract and slows its pharmacological effect as an anti-inflammatory. Mesoporous silica nanoparticles (MSN) are carriers that have the potential I to increase the solubility of poorly water-soluble drugs such as EPMC. tial to This study aims to load EPMC in MSN (EPMC-MSN) to increase the solubility of EPMC in water. MSN was prepared by using sodium silica as precursor and tween 80 and span 80 as template. A total of 500 mg of MSN was dispersed in 2% w/v EPMC solution, stirred at 100 rpm for 24 hours. The EPMC-MSN formed was then analyzed for Loading Capacity (LC) and Loading Efficiency (LE), characterized for particle size, surface area, pore diameter and volume, internal morphology. functional groups, and crystallinity, as well as solubility test. The results showed that MSN was a white powder with an irregular shape, particle size 87.1305 nm, surface area 68.86 m²/g, pore diameter 20.45 nm, pore volume 0.352 cm³/g, and low crystallinity. EPMC-MSN is a white powder that has a diffractogram pattern and IR spectrum corresponding to MSN, with LC 10.6% and LE 18.18% The solubility test showed that the solubility of EPMC-MSN in water increased by 1.7 folds compared to EPMC. Thus, it can be concluded that the loading of EPMC in MSN has the potential to increase the solubility of EPMC in water.

Item Type: Thesis (Skripsi)
Uncontrolled Keywords: Kelarutan, Etil p-Metoksisinamat, Mesopori Silika Nanopartikel. ---- Solubility, Ethyl p-methoxycinnamate, Mesoporous Silica Nanoparticles
Subjects: R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Divisions: Program Studi S1 Farmasi
Depositing User: pustakawan - -
Date Deposited: 14 Aug 2024 04:11
Last Modified: 14 Aug 2024 04:11
URI: http://repository.stfi.ac.id/id/eprint/816

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