AKTIVITAS ANTIOKSIDAN GRANUL INSTAN EKSTRAK ETANOL 70% BUNGA TELANG (Clitoria ternatea L.)

EVA MONICA ELISABET SITANGGANG, - (2026) AKTIVITAS ANTIOKSIDAN GRANUL INSTAN EKSTRAK ETANOL 70% BUNGA TELANG (Clitoria ternatea L.). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Bunga telang (Clitoria ternatea L) merupakan tanaman yang mengandung senyawa metabolit sekunder polar seperti flavonoid, fenol, dan antosianin yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk memformulasikan ekstrak etanol 70% bunga telang menjadi sediaan granul instan, mengevaluasi karakteristik fisik granul, serta menentukan aktivitas antioksidan menggunakan metode DPPH. Granul instan dibuat dalam tiga formula dengan variasi konsentrasi ekstrak, kemudian dilakukan evaluasi karakteristik fisik yang meliputi organoleptik, laju alir, sudut istirahat, kompresibilitas, kadar lembab, dan waktu larut. Aktivitas antioksidan ditentukan menggunakan spektrofotometer Uv-Vis dengan parameter IC₅₀. Hasil penelitian menunjukkan bahwa seluruh formula granul memenuhi persyaratan karakteristik fisik granul. Ekstrak etanol 70% bunga telang memiliki nilai IC₅₀ sebesar 86,47 µg/mL, sedangkan nilai IC₅₀ granul instan yaitu F1 1289,72µg/mL, F2 240,17µg/mL, dan F3 211,32µg/mL. Dapat disimpulkan, ekstrak etanol 70% bunga telang dapat diformulasikan menjadi granul instan yang memenuhi persyaratan mutu fisik. Aktivitas antioksidan pada ketiga formula granul instan lebih rendah daripada ekstrak etanol 70%. F3 memiliki aktivitas antioksidan lebih baik daripada F1 dan F2. ------ Butterfly pea (Clitoria ternatea L.) is a plant containing polar secondary metabolites, such as flavonoids, phenolic compounds and anthocyanins, which possess antioxidant properties. This study aimed to formulate a 70% ethanolic extract of butterfly pea flower into an instant granule dosage form, evaluate its physical characteristics, and determine its antioxidant activity using the DPPH method. Instant granules were prepared in theree formulations with different ectract concentrations. The physical characteristics evaluated included organoleptic properties, flow rate, angle of repose, compressibility, moisture content, and dissolution time. Antioxidant activity was determined using a Uv-Vis spectrophotometer and expressed as the IC₅₀ value. The results showed that all instant granule formulations met the required physical quality parameters. The 70% ethanolic extract of butterfly pea flower exhibiteed an IC₅₀ value of 86,47µg/mL, while the IC50 values of the instant granules were 1289,72µg/mL (F1), 240,17µg/Ml (F2), and 211,32µg/mL (F3). In conclusion, the 70% ethanolic extract of butterfly pea flower can be successfully formulated into an instant granule dosage form that meets the required physical quality standards. However, the antioxidant activity of all instant granule formulations was lower than that of the 70% ethanolic extract. Among the three formulations, F3 exhibited the highest antioxidant activity.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	bunga telang, granul instan, aktivitas antioksidan, DPPH, IC₅₀. ----- Clitoria ternatea L., instant granules, antioxidant activity, DPPH, IC₅₀.
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	24 Sep 2026 03:07
Last Modified:	24 Sep 2026 03:07
URI:	http://repository.stfi.ac.id/id/eprint/4313

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