AKTIVITAS ANTIBAKTERI INFUSA DAN KOMBUCHA BUNGA TELANG (Clitoria ternatea L.) TERHADAP Cutibacterium acnes

ELPA NABILA, - (2026) AKTIVITAS ANTIBAKTERI INFUSA DAN KOMBUCHA BUNGA TELANG (Clitoria ternatea L.) TERHADAP Cutibacterium acnes. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

	Text S_PSSF_A221013_Title.pdf Download (655kB)
	Text S_PSSF_A221013_Chapter1.pdf Restricted to Repository staff only Download (219kB)
	Text S_PSSF_A221013_Chapter2.pdf Restricted to Repository staff only Download (408kB)
	Text S_PSSF_A221013_Chapter3.pdf Restricted to Repository staff only Download (416kB)
	Text S_PSSF_A221013_Chapter4.pdf Restricted to Repository staff only Download (425kB)
	Text S_PSSF_A221013_Chapter5.pdf Restricted to Repository staff only Download (193kB)
	Text S_PSSF_A221013_Appendix.pdf Restricted to Repository staff only Download (2MB)

Abstract

Jerawat merupakan penyakit kulit yang salah satunya disebabkan oleh bakteri Cutibacterium acnes. Bunga telang (Clitoria ternatea L.) diketahui mengandung senyawa bioaktif yang berpotensi sebagai antibakteri dan aktivitasnya diduga meningkat setelah difermentasi menjadi kombucha. Penelitian ini bertujuan mengevaluasi aktivitas antibakteri ekstrak infusa dan kombucha bunga telang terhadap Cutibacterium acnes serta menganalisis perbedaan aktivitasnya menggunakan metode mikrodilusi well plate. Simplisia bunga telang diekstraksi dengan metode infusa, teh bunga telang dibuat melalui penyeduhan dengan air mendidih, sedangkan kombucha difermentasi selama 14 hari dengan variasi gula 10%, 15%, dan 20%. Hasil skrining fitokimia menunjukkan bahwa kombucha tetap mengandung flavonoid, fenol, tanin, saponin, dan triterpenoid setelah fermentasi. Pengujian pH menunjukkan nilai pH ekstrak infusa, teh bunga telang, dan kombucha gula 10%, 15%, dan 20% berturut-turut sebesar 4,23; 5,13; 3,18; 3,05; dan 3,02. Ekstrak bunga telang memiliki nilai KHM dan KBM sebesar 10.000 ppm, sedangkan seluruh kombucha memiliki nilai KHM dan KBM sebesar 2.500 ppm. Teh bunga telang tidak menunjukkan aktivitas antibakteri hingga konsentrasi 10.000 ppm. Berdasarkan hasil tersebut, kombucha bunga telang memiliki aktivitas antibakteri lebih tinggi dibandingkan ekstrak infusa dan teh bunga telang terhadap Cutibacterium acnes. ------- Acne is a common skin disorder, one of which is associated with Cutibacterium acnes. Butterfly pea flower (Clitoria ternatea L.) contains bioactive compounds with antibacterial potential, and its activity is expected to increase following kombucha fermentation. This study aimed to evaluate the antibacterial activity of butterfly pea flower infusion extract and kombucha against Cutibacterium acnes and to compare their antibacterial activities using the broth microdilution wellplate method. Butterfly pea flower simplicia were extracted using the infusion method, butterfly pea flower tea was prepared by steeping the dried simplicia in boiling water, whereas kombucha was produced by fermenting the infusion for 14 days with sugar concentrations of 10%, 15%, and 20%. Phytochemical screening showed that kombucha retained flavonoids, phenolics, tannins, saponins, and triterpenoids after fermentation. The pH values of the infusion extract, butterfly pea flower tea, and kombucha containing 10%, 15%, and 20% sugar were 4.23, 5.13, 3.18, 3.05, and 3.02, respectively. The infusion extract exhibited minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 10,000 ppm, whereas all kombucha samples exhibited MIC and MBC values of 2,500 ppm. Butterfly pea flower tea showed no antibacterial activity up to the highest tested concentration of 10,000 ppm. These findings indicate that butterfly pea flower kombucha exhibited greater antibacterial activity against Cutibacterium acnes than both the infusion extract and butterfly pea flower tea

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	bunga, telang, kombucha, antibakteri. ----- butterfly pea flower, kombucha, antibacterial
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	24 Sep 2026 02:41
Last Modified:	24 Sep 2026 02:41
URI:	http://repository.stfi.ac.id/id/eprint/4309

Actions (login required)

View Item