ANNISA REGITA CAHYANI, - (2026) PENINGKATAN LAJU DISOLUSI PIROKSIKAM MELALUI FORMULASI TABLET DENGAN VARIASI PRIMOGEL SEBAGAI BAHAN PENGHANCUR. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Piroksikam merupakan obat antiinflamasi nonsteroid (AINS) yang termasuk dalam Biopharmaceutical Classification System (BCS) kelas II, yaitu memiliki permeabilitas tinggi tetapi kelarutan rendah sehingga laju disolusi menjadi faktor pembatas absorpsinya. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi Primogel sebagai bahan penghancur terhadap laju disolusi tablet piroksikam. Tablet dibuat dengan metode granulasi basah menggunakan tujuh formula, yaitu F1 dan F2 sebagai formula pembanding berbasis Avicel PH 101 dengan dosis piroksikam masing-masing 10 mg dan 20 mg, sedangkan F3–F7 menggunakan Primogel dengan konsentrasi 4–8%. Evaluasi meliputi karakteristik granul dan tablet, penetapan kadar, serta uji disolusi dalam medium HCl 0,01 N. Hasil menunjukkan seluruh formula memenuhi persyaratan karakteristik fisik granul dan tablet. Pada penetapan kadar, F2, F3, F6 dan F7 memenuhi rentang Farmakope Indonesia Edisi VI (90,0–110,0%), sedangkan F1, F4, dan F5 tidak memenuhi syarat. Peningkatan konsentrasi Primogel secara konsisten meningkatkan persentase disolusi, dengan F7 (8%) memberikan hasil tertinggi. Enam dari tujuh formula (F1, F3–F7) memenuhi syarat disolusi Farmakope Indonesia Edisi VI, yaitu Q≥70% dalam 40 menit, sedangkan F2 tidak memenuhi. Dengan demikian, variasi konsentrasi Primogel berpengaruh terhadap laju disolusi tablet piroksikam, dengan konsentrasi 8% menghasilkan persentase terdisolusi yang paling tinggi. ------ Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) classified as a Class II drug according to the Biopharmaceutical Classification System (BCS), with high permeability but low solubility, making dissolution rate a limiting factor for its absorption. This study aimed to determine the effect of varying Primogel concentrations as a disintegrant on the dissolution rate of piroxicam tablets. Tablets were prepared by wet granulation using seven formulations: F1 and F2 as comparator formulations using Avicel PH 101, containing 10 mg and 20 mg piroxicam, respectively, while F3–F7 used Primogel at concentrations of 4–8%. Evaluations included granule and tablet characteristics, assay, and dissolution testing in 0.01 N HCl medium. All formulations met the physical characteristic requirements for granules and tablets. In the assay test, F2, F3, F6, and F7 met the Indonesian Pharmacopoeia Sixth Edition requirements (90.0–110.0%), while F1, F4, and F5 did not. Increasing Primogel concentration consistently increased the dissolution percentage, with F7 (8%) yielding the highest result. Six of the seven formulations (F1, F3–F7) met the dissolution requirement (Q ≥ 70% within 40 minutes), while F2 did not. Thus, variation in Primogel concentration affected the dissolution rate of piroxicam tablets, with a concentration of 8% producing the highest percentage dissolved.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | piroksikam, primogel, tablet, disolusi. ------- piroxicam, primogel, tablet, dissolution. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 24 Sep 2026 01:54 |
| Last Modified: | 24 Sep 2026 01:54 |
| URI: | http://repository.stfi.ac.id/id/eprint/4298 |
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